Fatty acid composition of plasma lipid classes in chronic alcoholic pancreatitis

Tamas Marosvolgyi, Gabor Horvath, Aniko Dittrich, Judit Cseh, Zsuzsanna Lelovics, Eva Szabo, T. Decsi, M. Figler

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background/Aims: Supplementation of n-3 long-chain polyunsaturated fatty acids (LCPUFA) is considered as adjuvant therapy in acute pancreatitis. We investigated plasma fatty acid status in chronic pancreatitis (CP). Methods: Patients with alcoholic CP (n = 56, gender: 33/23 male/female, age: 60.0 [14.0] years (median [IQR]), who reported giving up alcohol consumption several years ago and 51 control subjects were included into the study. The fatty acid composition of plasma phospholipids (PL), triacylglycerols (TG) and sterol esters (STE) was analyzed. Results: The sum of monounsaturated fatty acids was significantly higher in patients with CP than in controls (PL: 12.83 [3.35] vs. 12.20 [1.95], TG: 40.51 [6.02] vs. 37.52 [5.80], STE: 20.58 [7.22] vs. 17.54 [3.48], CP vs. control, % weight/weight, median [IQR], p <0.05). Values of arachidonic acid were significantly lower in patients with CP than in controls (PL: 10.57 [3.56] vs. 11.66 [3.25], STE: 8.14 [2.63] vs. 9.24 [2.86], p <0.05). Values of eicosapentaenoic acid and docosahexaenoic acid did not differ and there was no difference in the ratio of n-3 to n-6 LCPUFA. Conclusion: Our present data do not furnish evidence for the supplementation of n-3 LCPUFA to the diet of CP patients in relatively good clinical condition.

Original languageEnglish
Pages (from-to)580-585
Number of pages6
JournalPancreatology
Volume10
Issue number5
DOIs
Publication statusPublished - Dec 2010

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Alcoholic Pancreatitis
Chronic Pancreatitis
Fatty Acids
Lipids
Sterols
Unsaturated Fatty Acids
Phospholipids
Esters
Triglycerides
Weights and Measures
Monounsaturated Fatty Acids
Eicosapentaenoic Acid
Docosahexaenoic Acids
Arachidonic Acid
Alcohol Drinking
Pancreatitis
Diet

Keywords

  • Alcoholic chronic pancreatitis
  • Arachidonic acid
  • Polyunsaturated fatty acids

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology

Cite this

Marosvolgyi, T., Horvath, G., Dittrich, A., Cseh, J., Lelovics, Z., Szabo, E., ... Figler, M. (2010). Fatty acid composition of plasma lipid classes in chronic alcoholic pancreatitis. Pancreatology, 10(5), 580-585. https://doi.org/10.1159/000289466

Fatty acid composition of plasma lipid classes in chronic alcoholic pancreatitis. / Marosvolgyi, Tamas; Horvath, Gabor; Dittrich, Aniko; Cseh, Judit; Lelovics, Zsuzsanna; Szabo, Eva; Decsi, T.; Figler, M.

In: Pancreatology, Vol. 10, No. 5, 12.2010, p. 580-585.

Research output: Contribution to journalArticle

Marosvolgyi, T, Horvath, G, Dittrich, A, Cseh, J, Lelovics, Z, Szabo, E, Decsi, T & Figler, M 2010, 'Fatty acid composition of plasma lipid classes in chronic alcoholic pancreatitis', Pancreatology, vol. 10, no. 5, pp. 580-585. https://doi.org/10.1159/000289466
Marosvolgyi T, Horvath G, Dittrich A, Cseh J, Lelovics Z, Szabo E et al. Fatty acid composition of plasma lipid classes in chronic alcoholic pancreatitis. Pancreatology. 2010 Dec;10(5):580-585. https://doi.org/10.1159/000289466
Marosvolgyi, Tamas ; Horvath, Gabor ; Dittrich, Aniko ; Cseh, Judit ; Lelovics, Zsuzsanna ; Szabo, Eva ; Decsi, T. ; Figler, M. / Fatty acid composition of plasma lipid classes in chronic alcoholic pancreatitis. In: Pancreatology. 2010 ; Vol. 10, No. 5. pp. 580-585.
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AB - Background/Aims: Supplementation of n-3 long-chain polyunsaturated fatty acids (LCPUFA) is considered as adjuvant therapy in acute pancreatitis. We investigated plasma fatty acid status in chronic pancreatitis (CP). Methods: Patients with alcoholic CP (n = 56, gender: 33/23 male/female, age: 60.0 [14.0] years (median [IQR]), who reported giving up alcohol consumption several years ago and 51 control subjects were included into the study. The fatty acid composition of plasma phospholipids (PL), triacylglycerols (TG) and sterol esters (STE) was analyzed. Results: The sum of monounsaturated fatty acids was significantly higher in patients with CP than in controls (PL: 12.83 [3.35] vs. 12.20 [1.95], TG: 40.51 [6.02] vs. 37.52 [5.80], STE: 20.58 [7.22] vs. 17.54 [3.48], CP vs. control, % weight/weight, median [IQR], p <0.05). Values of arachidonic acid were significantly lower in patients with CP than in controls (PL: 10.57 [3.56] vs. 11.66 [3.25], STE: 8.14 [2.63] vs. 9.24 [2.86], p <0.05). Values of eicosapentaenoic acid and docosahexaenoic acid did not differ and there was no difference in the ratio of n-3 to n-6 LCPUFA. Conclusion: Our present data do not furnish evidence for the supplementation of n-3 LCPUFA to the diet of CP patients in relatively good clinical condition.

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