Fatigue in psoriatic arthritis - a cross-sectional study of 246 patients from 13 countries

Tania Gudu, Adrien Etcheto, Maarten de Wit, Turid Heiberg, Mara Maccarone, Andra Balanescu, P. Bálint, Dora S. Niedermayer, Juan D. Cañete, Philip Helliwell, Umut Kalyoncu, Uta Kiltz, Kati Otsa, Douglas J. Veale, Kurt de Vlam, Rossana Scrivo, Tanja Stamm, Tore K. Kvien, Laure Gossec

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: Fatigue is an aspect of psoriatic arthritis (PsA), which is important to patients. The objective was to evaluate magnitude of fatigue in PsA patients and to assess factors that might explain high levels of fatigue. Methods: This was an ancillary analysis of a cross-sectional study in 13 countries of unselected PsA patients who fulfilled the CASPAR criteria. Patient-perceived importance of fatigue was assessed through a priority exercise. Levels of fatigue were assessed by a numeric rating scale (range 0-10). Factors potentially associated with fatigue. >. 5/10: i.e., demographic variables (age, gender, disease duration, education level) and disease related characteristics including joint counts, C-reactive protein, skin psoriasis, axial involvement, enthesitis, dactylitis, structural damage, were assessed by univariate, multivariate logistic and multiple linear regression. Results: In all, 246 patients were analysed: mean. ±. standard deviation age 51.2. ±. 13.0. years, mean disease duration 9.9. ±. 10.1. years, mean DAS28 3.5. ±. 1.3. Fatigue was ranked second in patient-perceived importance, after pain. Magnitude of fatigue was high: mean fatigue 5.0. ±. 3.0. Fatigue. >. 5/10 was well explained (variance explained 73%) by skin psoriasis (odds ratio 4.67 [95% confidence interval 1.05; 20.72]), tender joints (1.30 [1.01; 1.68]) and lower education level (1.09 [1.02; 1.23]). In the multiple linear regression model, fatigue was explained by skin psoriasis, tender joints, enthesitis, female gender, education level. Conclusions: Fatigue is a priority for PsA patients. Fatigue levels were high in these patients and fatigue. >. 5/10 was mainly associated with disease-related factors but also patient-related variables, indicating that the etiology of fatigue in PsA is multifactorial.

Original languageEnglish
JournalJoint Bone Spine
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Psoriatic Arthritis
Fatigue
Cross-Sectional Studies
Psoriasis
Linear Models
Joints
Education
Skin
C-Reactive Protein

Keywords

  • Fatigue
  • Patient perspective
  • Psoriatic arthritis
  • Quality of life

ASJC Scopus subject areas

  • Rheumatology

Cite this

Gudu, T., Etcheto, A., de Wit, M., Heiberg, T., Maccarone, M., Balanescu, A., ... Gossec, L. (Accepted/In press). Fatigue in psoriatic arthritis - a cross-sectional study of 246 patients from 13 countries. Joint Bone Spine. https://doi.org/10.1016/j.jbspin.2015.07.017

Fatigue in psoriatic arthritis - a cross-sectional study of 246 patients from 13 countries. / Gudu, Tania; Etcheto, Adrien; de Wit, Maarten; Heiberg, Turid; Maccarone, Mara; Balanescu, Andra; Bálint, P.; Niedermayer, Dora S.; Cañete, Juan D.; Helliwell, Philip; Kalyoncu, Umut; Kiltz, Uta; Otsa, Kati; Veale, Douglas J.; de Vlam, Kurt; Scrivo, Rossana; Stamm, Tanja; Kvien, Tore K.; Gossec, Laure.

In: Joint Bone Spine, 2016.

Research output: Contribution to journalArticle

Gudu, T, Etcheto, A, de Wit, M, Heiberg, T, Maccarone, M, Balanescu, A, Bálint, P, Niedermayer, DS, Cañete, JD, Helliwell, P, Kalyoncu, U, Kiltz, U, Otsa, K, Veale, DJ, de Vlam, K, Scrivo, R, Stamm, T, Kvien, TK & Gossec, L 2016, 'Fatigue in psoriatic arthritis - a cross-sectional study of 246 patients from 13 countries', Joint Bone Spine. https://doi.org/10.1016/j.jbspin.2015.07.017
Gudu, Tania ; Etcheto, Adrien ; de Wit, Maarten ; Heiberg, Turid ; Maccarone, Mara ; Balanescu, Andra ; Bálint, P. ; Niedermayer, Dora S. ; Cañete, Juan D. ; Helliwell, Philip ; Kalyoncu, Umut ; Kiltz, Uta ; Otsa, Kati ; Veale, Douglas J. ; de Vlam, Kurt ; Scrivo, Rossana ; Stamm, Tanja ; Kvien, Tore K. ; Gossec, Laure. / Fatigue in psoriatic arthritis - a cross-sectional study of 246 patients from 13 countries. In: Joint Bone Spine. 2016.
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abstract = "Objectives: Fatigue is an aspect of psoriatic arthritis (PsA), which is important to patients. The objective was to evaluate magnitude of fatigue in PsA patients and to assess factors that might explain high levels of fatigue. Methods: This was an ancillary analysis of a cross-sectional study in 13 countries of unselected PsA patients who fulfilled the CASPAR criteria. Patient-perceived importance of fatigue was assessed through a priority exercise. Levels of fatigue were assessed by a numeric rating scale (range 0-10). Factors potentially associated with fatigue. >. 5/10: i.e., demographic variables (age, gender, disease duration, education level) and disease related characteristics including joint counts, C-reactive protein, skin psoriasis, axial involvement, enthesitis, dactylitis, structural damage, were assessed by univariate, multivariate logistic and multiple linear regression. Results: In all, 246 patients were analysed: mean. ±. standard deviation age 51.2. ±. 13.0. years, mean disease duration 9.9. ±. 10.1. years, mean DAS28 3.5. ±. 1.3. Fatigue was ranked second in patient-perceived importance, after pain. Magnitude of fatigue was high: mean fatigue 5.0. ±. 3.0. Fatigue. >. 5/10 was well explained (variance explained 73{\%}) by skin psoriasis (odds ratio 4.67 [95{\%} confidence interval 1.05; 20.72]), tender joints (1.30 [1.01; 1.68]) and lower education level (1.09 [1.02; 1.23]). In the multiple linear regression model, fatigue was explained by skin psoriasis, tender joints, enthesitis, female gender, education level. Conclusions: Fatigue is a priority for PsA patients. Fatigue levels were high in these patients and fatigue. >. 5/10 was mainly associated with disease-related factors but also patient-related variables, indicating that the etiology of fatigue in PsA is multifactorial.",
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AU - Maccarone, Mara

AU - Balanescu, Andra

AU - Bálint, P.

AU - Niedermayer, Dora S.

AU - Cañete, Juan D.

AU - Helliwell, Philip

AU - Kalyoncu, Umut

AU - Kiltz, Uta

AU - Otsa, Kati

AU - Veale, Douglas J.

AU - de Vlam, Kurt

AU - Scrivo, Rossana

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