Fast vaccine design and development based on correlates of protection (COPs): Influenza as a trendsetter

Cécile Van Els, Siri Mjaaland, Lisbeth Næss, Julia Sarkadi, Eva Gonczol, Karen Smith Korsholm, Jon Hansen, Jørgen De Jonge, Gideon Kersten, Jennifer Warner, Amanda Semper, Corine Kruiswijk, Fredrik Oftung

Research output: Contribution to journalReview article

10 Citations (Scopus)


New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element. In emergency situations, when time is limited, identification and use of correlates of protection (COPs) may play a key role as a strategic tool for accelerated vaccine design, testing, and licensure. We propose that general rules for COP-based vaccine design can be extracted from the existing knowledge of protective immune responses against a large spectrum of relevant viral and bacterial pathogens. Herein, we focus on the applicability of this approach by reviewing the established and up-coming COPs for influenza in the context of traditional and a wide array of new vaccine concepts. The lessons learnt from this field may be applied more generally to COP-based accelerated vaccine design for emerging infections.

Original languageEnglish
Pages (from-to)1935-1948
Number of pages14
JournalHuman Vaccines and Immunotherapeutics
Issue number7
Publication statusPublished - Jul 1 2014



  • COP based vaccine design
  • Correlates of protection
  • Influenza
  • Vaccine development

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Van Els, C., Mjaaland, S., Næss, L., Sarkadi, J., Gonczol, E., Korsholm, K. S., Hansen, J., De Jonge, J., Kersten, G., Warner, J., Semper, A., Kruiswijk, C., & Oftung, F. (2014). Fast vaccine design and development based on correlates of protection (COPs): Influenza as a trendsetter. Human Vaccines and Immunotherapeutics, 10(7), 1935-1948.