Fast positive feedback between the adrenocortical stress response and a brain mechanism involved in aggressive behavior

Menno R. Kruk, Wout Meelis, József Halász, József Haller

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Aggressive behavior induces an adrenocortical stress response, and sudden stressors often precipitate violent behavior. Experiments in rats revealed a fast, mutual, positive feedback between the adrenocortical stress response and a brain mechanism controlling aggression. Stimulation of the aggressive area in the hypothalamus rapidly activated the adrenocortical response, even in the absence of an opponent and fighting. Hypothalamic aggression, in turn, was rapidly facilitated by a corticosterone injection in rats in which the natural adrenocortical stress response was prevented by adrenalectomy. The rapidity of both effects points to a fast, mutual, positive feedback of the controlling mechanisms within the time frame of a single conflict. Such a mutual facilitation may contribute to the precipitation and escalation of violent behavior under stressful conditions.

Original languageEnglish
Pages (from-to)1062-1070
Number of pages9
JournalBehavioral Neuroscience
Volume118
Issue number5
DOIs
Publication statusPublished - Oct 1 2004

ASJC Scopus subject areas

  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Fast positive feedback between the adrenocortical stress response and a brain mechanism involved in aggressive behavior'. Together they form a unique fingerprint.

  • Cite this