Fast atom bombardment mass spectrometry of some lantibiotics

Miklós Lipták, Károly Vékey, William D. van Dongen, Wigger Heerma

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Abstract

Four lantibiotics namely epidermin, gallidermin, lanthiopeptin and mersacidin, have been studied by fast atom bombardment mass spectrometry. The molecular ion clusters of these compounds can be detected with reasonable abundance. The low‐mass regions of the spectra show the presence of ions characteristic of the amino acids in the peptides. The mass distribution of the sequence ions provides information about the location of sulphur bridges the occurrence of which is a common feature of these kinds of molecules. The two isomeric compounds epidermin and gallidermin differ only in a leucine/isoleucine exchange at position 6. These two compounds can be distinguished on the basis of the tandem mass spectrum of m/z 86, the immonium ion of leucine and isoleucine.

Original languageEnglish
Pages (from-to)701-706
Number of pages6
JournalBiological Mass Spectrometry
Volume23
Issue number11
DOIs
Publication statusPublished - Nov 1994

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

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