Family Juncaceae

promising source of biologically active natural phenanthrenes

Csaba Bús, Barbara Tóth, Dóra Stefkó, J. Hohmann, Andrea Vasas

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Phenanthrenes represent a relatively small group of aromatic secondary metabolites, which can be divided into three main subgroups (mono-, di-, and triphenanthrenes). Phenanthrenes are reported as an intensively researched field in phytochemistry according to their structural diversity and promising biological activities. Because of their limited occurrence phenanthrenes are considered to be as important taxonomic markers. Juncaceae is a relatively large plant family divided into seven genera of which Juncus and Luzula are the most important ones from phytochemical and pharmacological points of view. To date, almost one hundred natural phenanthrenes have been isolated but only from eight (Juncus acutus, J. effusus, J. inflexus, J. maritimus, J. roemerianus, J. setchuensis, J. subulatus, and Luzula luzuloides) Juncaceae species, including mono-, and diphenanthrenes, and phenanthrene glucosides. Great deal of the isolated compounds are substituted with a vinyl group. This substitution is characteristic exclusively to Juncaceae species. Juncusol (2) was isolated from every investigated species. The richest source of phenanthrenes, as well as the most extensively investigated species is J. effusus. Several isolated compounds possessed different biological activities, e.g. antiproliferative, antimicrobial, anti-inflammatory, antioxidant, spasmolytic, anxiolytic, and antialgal effects. Among them, dehydroeffusol (60) is the most promising one, as it showed antimicrobial, anxiolytic, sedative, spasmolytic, cellular protective and antiproliferative activities. The aim of this review is to summarize the occurrence of phenanthrenes in the family Juncaceae, and give a comprehensive overview of their isolation, structural characteristics and biological activities.

Original languageEnglish
Pages (from-to)1-19
Number of pages19
JournalPhytochemistry Reviews
DOIs
Publication statusAccepted/In press - Mar 21 2018

Fingerprint

Phenanthrenes
Juncaceae
phenanthrene
Parasympatholytics
Luzula
parasympatholytics
bioactive properties
Anti-Anxiety Agents
tranquilizers
anti-infective agents
Juncus roemerianus
Juncus effusus
Biodiversity
Glucosides
Phytochemicals
Juncus
plant biochemistry
sedatives
Hypnotics and Sedatives
Anti-Inflammatory Agents

Keywords

  • Biological activities
  • Juncaceae
  • Juncus
  • Luzula
  • Phenanthrenes

ASJC Scopus subject areas

  • Biotechnology
  • Plant Science

Cite this

Family Juncaceae : promising source of biologically active natural phenanthrenes. / Bús, Csaba; Tóth, Barbara; Stefkó, Dóra; Hohmann, J.; Vasas, Andrea.

In: Phytochemistry Reviews, 21.03.2018, p. 1-19.

Research output: Contribution to journalArticle

Bús, Csaba ; Tóth, Barbara ; Stefkó, Dóra ; Hohmann, J. ; Vasas, Andrea. / Family Juncaceae : promising source of biologically active natural phenanthrenes. In: Phytochemistry Reviews. 2018 ; pp. 1-19.
@article{27146d4347914819bec1de6c391133e4,
title = "Family Juncaceae: promising source of biologically active natural phenanthrenes",
abstract = "Phenanthrenes represent a relatively small group of aromatic secondary metabolites, which can be divided into three main subgroups (mono-, di-, and triphenanthrenes). Phenanthrenes are reported as an intensively researched field in phytochemistry according to their structural diversity and promising biological activities. Because of their limited occurrence phenanthrenes are considered to be as important taxonomic markers. Juncaceae is a relatively large plant family divided into seven genera of which Juncus and Luzula are the most important ones from phytochemical and pharmacological points of view. To date, almost one hundred natural phenanthrenes have been isolated but only from eight (Juncus acutus, J. effusus, J. inflexus, J. maritimus, J. roemerianus, J. setchuensis, J. subulatus, and Luzula luzuloides) Juncaceae species, including mono-, and diphenanthrenes, and phenanthrene glucosides. Great deal of the isolated compounds are substituted with a vinyl group. This substitution is characteristic exclusively to Juncaceae species. Juncusol (2) was isolated from every investigated species. The richest source of phenanthrenes, as well as the most extensively investigated species is J. effusus. Several isolated compounds possessed different biological activities, e.g. antiproliferative, antimicrobial, anti-inflammatory, antioxidant, spasmolytic, anxiolytic, and antialgal effects. Among them, dehydroeffusol (60) is the most promising one, as it showed antimicrobial, anxiolytic, sedative, spasmolytic, cellular protective and antiproliferative activities. The aim of this review is to summarize the occurrence of phenanthrenes in the family Juncaceae, and give a comprehensive overview of their isolation, structural characteristics and biological activities.",
keywords = "Biological activities, Juncaceae, Juncus, Luzula, Phenanthrenes",
author = "Csaba B{\'u}s and Barbara T{\'o}th and D{\'o}ra Stefk{\'o} and J. Hohmann and Andrea Vasas",
year = "2018",
month = "3",
day = "21",
doi = "10.1007/s11101-018-9561-5",
language = "English",
pages = "1--19",
journal = "Phytochemistry Reviews",
issn = "1568-7767",
publisher = "Springer Netherlands",

}

TY - JOUR

T1 - Family Juncaceae

T2 - promising source of biologically active natural phenanthrenes

AU - Bús, Csaba

AU - Tóth, Barbara

AU - Stefkó, Dóra

AU - Hohmann, J.

AU - Vasas, Andrea

PY - 2018/3/21

Y1 - 2018/3/21

N2 - Phenanthrenes represent a relatively small group of aromatic secondary metabolites, which can be divided into three main subgroups (mono-, di-, and triphenanthrenes). Phenanthrenes are reported as an intensively researched field in phytochemistry according to their structural diversity and promising biological activities. Because of their limited occurrence phenanthrenes are considered to be as important taxonomic markers. Juncaceae is a relatively large plant family divided into seven genera of which Juncus and Luzula are the most important ones from phytochemical and pharmacological points of view. To date, almost one hundred natural phenanthrenes have been isolated but only from eight (Juncus acutus, J. effusus, J. inflexus, J. maritimus, J. roemerianus, J. setchuensis, J. subulatus, and Luzula luzuloides) Juncaceae species, including mono-, and diphenanthrenes, and phenanthrene glucosides. Great deal of the isolated compounds are substituted with a vinyl group. This substitution is characteristic exclusively to Juncaceae species. Juncusol (2) was isolated from every investigated species. The richest source of phenanthrenes, as well as the most extensively investigated species is J. effusus. Several isolated compounds possessed different biological activities, e.g. antiproliferative, antimicrobial, anti-inflammatory, antioxidant, spasmolytic, anxiolytic, and antialgal effects. Among them, dehydroeffusol (60) is the most promising one, as it showed antimicrobial, anxiolytic, sedative, spasmolytic, cellular protective and antiproliferative activities. The aim of this review is to summarize the occurrence of phenanthrenes in the family Juncaceae, and give a comprehensive overview of their isolation, structural characteristics and biological activities.

AB - Phenanthrenes represent a relatively small group of aromatic secondary metabolites, which can be divided into three main subgroups (mono-, di-, and triphenanthrenes). Phenanthrenes are reported as an intensively researched field in phytochemistry according to their structural diversity and promising biological activities. Because of their limited occurrence phenanthrenes are considered to be as important taxonomic markers. Juncaceae is a relatively large plant family divided into seven genera of which Juncus and Luzula are the most important ones from phytochemical and pharmacological points of view. To date, almost one hundred natural phenanthrenes have been isolated but only from eight (Juncus acutus, J. effusus, J. inflexus, J. maritimus, J. roemerianus, J. setchuensis, J. subulatus, and Luzula luzuloides) Juncaceae species, including mono-, and diphenanthrenes, and phenanthrene glucosides. Great deal of the isolated compounds are substituted with a vinyl group. This substitution is characteristic exclusively to Juncaceae species. Juncusol (2) was isolated from every investigated species. The richest source of phenanthrenes, as well as the most extensively investigated species is J. effusus. Several isolated compounds possessed different biological activities, e.g. antiproliferative, antimicrobial, anti-inflammatory, antioxidant, spasmolytic, anxiolytic, and antialgal effects. Among them, dehydroeffusol (60) is the most promising one, as it showed antimicrobial, anxiolytic, sedative, spasmolytic, cellular protective and antiproliferative activities. The aim of this review is to summarize the occurrence of phenanthrenes in the family Juncaceae, and give a comprehensive overview of their isolation, structural characteristics and biological activities.

KW - Biological activities

KW - Juncaceae

KW - Juncus

KW - Luzula

KW - Phenanthrenes

UR - http://www.scopus.com/inward/record.url?scp=85044219417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044219417&partnerID=8YFLogxK

U2 - 10.1007/s11101-018-9561-5

DO - 10.1007/s11101-018-9561-5

M3 - Article

SP - 1

EP - 19

JO - Phytochemistry Reviews

JF - Phytochemistry Reviews

SN - 1568-7767

ER -