Family history and lung cancer risk: International multicentre case-control study in Eastern and Central Europe and meta-analyses

Jolanta Lissowska, Lenka Foretova, Joanna Da̧bek, David Zaridze, Neonila Szeszenia-Dabrowska, P. Rudnai, Eleonora Fabianova, Adrian Cassidy, Dana Mates, Vladimir Bencko, Vladimir Janout, Rayjean J. Hung, Paul Brennan, Paolo Boffetta

Research output: Contribution to journalArticle

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Abstract

Lung cancer is the most common neoplastic disease in Eastern and Central Europe. The role of hereditary factors in lung carcinogenesis is not fully understood. Family history (FH) of lung cancer and other tobaccorelated cancers might be a strong predictor of the lung cancer risk. We investigated family history of cancer among first-degree relatives of 2,861 patients with lung cancer and 3,118 controls from the Czech Republic, Hungary, Poland, Romania, Russia, Slovakia, and United Kingdom within the IARC Multicenter Case-Control Study. Odds ratios (ORs) and 95% CI were calculated using logistic regression, adjusting for age, gender, study center, education, tobacco smoking, and number of firstdegree relatives. In addition, we conducted a meta-analysis of 41 studies on FH of cancer and lung cancer risk. Positive FH of lung cancer increased risk of lung cancer with OR of 1.63 (95%CI: 1.31-2.01), and having two or more affected relatives with lung cancer further increased the risk of lung cancer with OR 3.60 (95%CI: 1.56-8.31). Among subjects aged less than 50, the OR for FH of lung cancer was 2.08 (95%CI: 1.18-3.63). The associations were generally stronger for squamous cell carcinoma and large cell carcinoma subtypes. Heterogeneity in results was not found with respect to smoking status and gender. A significant association was not observed for FH of other smokingrelated tumors. The results of meta-analysis were consistent with that of our study with regard to young onset, nonsmokers and histology. FH of lung cancer is a predictor of an increased risk of lung cancer, especially in subjects aged less than 50.

Original languageEnglish
Pages (from-to)1091-1104
Number of pages14
JournalCancer Causes and Control
Volume21
Issue number7
DOIs
Publication statusPublished - Jul 2010

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Eastern Europe
Meta-Analysis
Case-Control Studies
Lung Neoplasms
Odds Ratio
Smoking
Large Cell Carcinoma
Romania
Slovakia
Neoplasms
Hungary
Czech Republic
Russia
Poland
Squamous Cell Carcinoma
Histology

Keywords

  • Case-control study
  • Family history
  • Lung cancer
  • Meta-analyses

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Family history and lung cancer risk : International multicentre case-control study in Eastern and Central Europe and meta-analyses. / Lissowska, Jolanta; Foretova, Lenka; Da̧bek, Joanna; Zaridze, David; Szeszenia-Dabrowska, Neonila; Rudnai, P.; Fabianova, Eleonora; Cassidy, Adrian; Mates, Dana; Bencko, Vladimir; Janout, Vladimir; Hung, Rayjean J.; Brennan, Paul; Boffetta, Paolo.

In: Cancer Causes and Control, Vol. 21, No. 7, 07.2010, p. 1091-1104.

Research output: Contribution to journalArticle

Lissowska, J, Foretova, L, Da̧bek, J, Zaridze, D, Szeszenia-Dabrowska, N, Rudnai, P, Fabianova, E, Cassidy, A, Mates, D, Bencko, V, Janout, V, Hung, RJ, Brennan, P & Boffetta, P 2010, 'Family history and lung cancer risk: International multicentre case-control study in Eastern and Central Europe and meta-analyses', Cancer Causes and Control, vol. 21, no. 7, pp. 1091-1104. https://doi.org/10.1007/s10552-010-9537-2
Lissowska, Jolanta ; Foretova, Lenka ; Da̧bek, Joanna ; Zaridze, David ; Szeszenia-Dabrowska, Neonila ; Rudnai, P. ; Fabianova, Eleonora ; Cassidy, Adrian ; Mates, Dana ; Bencko, Vladimir ; Janout, Vladimir ; Hung, Rayjean J. ; Brennan, Paul ; Boffetta, Paolo. / Family history and lung cancer risk : International multicentre case-control study in Eastern and Central Europe and meta-analyses. In: Cancer Causes and Control. 2010 ; Vol. 21, No. 7. pp. 1091-1104.
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