Familial multiple myeloma. Two more families

J. Várkonyi, Péter Farkas, Júlia Tamáska, T. Masszi, László Gopcsa, Ágnes Padányi, K. Rajczy

Research output: Contribution to journalArticle

Abstract

The authors report on two multiple myeloma sibling pairs. In the absence of a known disease-specific marker one can only speculate on an explanation: Is it because of inherited errors or is it related to the same environmental exposure, or both? In this study HLA typing and metabolizing enzyme polymorphism studies have been carried out with the aim of finding inherited similarities in the siblings or characteristics that might differ from the average population. Sibling pair 1 shared an HLA haplotype. Sibling pair 2 shared only HLA-B51, DR4, DRw53, DQ3. Sibling 1/1 was GSTT1 / GSTM1 null and GSTP1 Ile105Val; sibling 1/2 was a GSTT1 / GSTM1 heterozygote and GSTP1 Ile105Val; sibling 2/1 and 2/2 were GSTT1 heterozygotes and shared GSTM1 null / GSTP1 Ile105Ile. The siblings had identical light chain or heavy chain secretion, or both. The similarities found in the inherited factors together with the same environmental exposure in the siblings' first 20 years of life imply that the development of the same disease cannot be a coincidence.

Original languageEnglish
Pages (from-to)501-505
Number of pages5
JournalCentral European Journal of Medicine
Volume4
Issue number4
DOIs
Publication statusPublished - Dec 2009

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Environmental Exposure
Heterozygote
Multiple Myeloma
HLA-B51 Antigen
HLA-DR4 Antigen
Histocompatibility Testing
Haplotypes
Light
Enzymes
Population

Keywords

  • Familial multiple myeloma
  • Genetic polymorphism
  • Henoch-schönlein purpura
  • Susceptibility to cancer

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Familial multiple myeloma. Two more families. / Várkonyi, J.; Farkas, Péter; Tamáska, Júlia; Masszi, T.; Gopcsa, László; Padányi, Ágnes; Rajczy, K.

In: Central European Journal of Medicine, Vol. 4, No. 4, 12.2009, p. 501-505.

Research output: Contribution to journalArticle

Várkonyi, J. ; Farkas, Péter ; Tamáska, Júlia ; Masszi, T. ; Gopcsa, László ; Padányi, Ágnes ; Rajczy, K. / Familial multiple myeloma. Two more families. In: Central European Journal of Medicine. 2009 ; Vol. 4, No. 4. pp. 501-505.
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