Familial dilated cardiomyopathy: A worse prognosis compared with sporadic forms

M. Csanády, M. Hogye, A. Kallai, T. Forster, T. Szarazajtai

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To establish the time of onset of dilated cardiomyopathy (DCM) by review of annual chest x rays, which are obligatory in Hungary. Design: A retrospective survey of chest x rays of a cohort of confirmed cases of DCM, to assess time of onset of cardiomegaly. Clinical course was compared by follow up over a mean of six years from the time of diagnosis. Subjects: 240 patients with DCM (31 familial, 209 non-familial). Diagnosis was made by echocardiography in all cases and confirmed by coronary angiography and heart biopsy in some cases. Main results: At diagnosis, the mean age of the patients was 31.8 years in the familial group and 39.6 years in the non-familial group (P <0.05). The time between the onset of cardiomegaly (cardiothoracic ratio >0.45) and clinical diagnosis was 8.0 and 10.1 years respectively (P <0.05). The six year survival was 6% in the familial group and 23% in the non-familial group (P <0.05). Conclusions: The familial form of DCM is the more malignant form: it occurs at an earlier age and progresses more rapidly than non-familial DCM.

Original languageEnglish
Pages (from-to)171-173
Number of pages3
JournalBritish Heart Journal
Volume74
Issue number2
Publication statusPublished - 1995

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Dilated Cardiomyopathy
Thorax
X-Rays
Hungary
Cardiomegaly
Coronary Angiography
Echocardiography
Biopsy
Survival
Familial dilated cardiomyopathy

Keywords

  • familial dilated cardiomyopathy
  • prognosis
  • sporadic cardiomyopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Familial dilated cardiomyopathy : A worse prognosis compared with sporadic forms. / Csanády, M.; Hogye, M.; Kallai, A.; Forster, T.; Szarazajtai, T.

In: British Heart Journal, Vol. 74, No. 2, 1995, p. 171-173.

Research output: Contribution to journalArticle

Csanády, M. ; Hogye, M. ; Kallai, A. ; Forster, T. ; Szarazajtai, T. / Familial dilated cardiomyopathy : A worse prognosis compared with sporadic forms. In: British Heart Journal. 1995 ; Vol. 74, No. 2. pp. 171-173.
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N2 - Objective: To establish the time of onset of dilated cardiomyopathy (DCM) by review of annual chest x rays, which are obligatory in Hungary. Design: A retrospective survey of chest x rays of a cohort of confirmed cases of DCM, to assess time of onset of cardiomegaly. Clinical course was compared by follow up over a mean of six years from the time of diagnosis. Subjects: 240 patients with DCM (31 familial, 209 non-familial). Diagnosis was made by echocardiography in all cases and confirmed by coronary angiography and heart biopsy in some cases. Main results: At diagnosis, the mean age of the patients was 31.8 years in the familial group and 39.6 years in the non-familial group (P <0.05). The time between the onset of cardiomegaly (cardiothoracic ratio >0.45) and clinical diagnosis was 8.0 and 10.1 years respectively (P <0.05). The six year survival was 6% in the familial group and 23% in the non-familial group (P <0.05). Conclusions: The familial form of DCM is the more malignant form: it occurs at an earlier age and progresses more rapidly than non-familial DCM.

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