Failure of oral E. coli O83 lipopolysaccharide to influence intestinal morphology and cell proliferation in rats

Short communication

G. Illyés, Krisztina Kovács, Béla Kocsis, Káraly Baintner

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

It is known that bacterial lipopolysaccharide (LPS) is not absorbed from the gastrointestinal tract in significant quantities. However, the question remained whether oral LPS modified the structure or function of the gut. In the present experiment Escherichia coli O83 LPS was administered to growing rats in repeated oral doses of 400 mg/kg body weight (b. w.), every 8 h. After three days of treatment, morphometric and histochemical examinations of the small intestine did not show significant differences between treated and control rats. It is concluded that repeated oral administration of high doses of E. coli O83 LPS had no demonstrable effect on intestinal structure and cell proliferation in a rat model.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalActa Veterinaria Hungarica
Volume56
Issue number1
DOIs
Publication statusPublished - Mar 2008

Fingerprint

animal communication
lipopolysaccharides
Lipopolysaccharides
mouth
cell proliferation
Communication
Cell Proliferation
Escherichia coli
rats
dosage
oral administration
Small Intestine
gastrointestinal system
Oral Administration
small intestine
Gastrointestinal Tract
digestive system
animal models
Body Weight
body weight

Keywords

  • Absorption
  • AgNOR
  • Ki67
  • Lipopolysaccharide
  • Morphometry
  • Rat
  • Small intestine
  • TUNEL

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Failure of oral E. coli O83 lipopolysaccharide to influence intestinal morphology and cell proliferation in rats : Short communication. / Illyés, G.; Kovács, Krisztina; Kocsis, Béla; Baintner, Káraly.

In: Acta Veterinaria Hungarica, Vol. 56, No. 1, 03.2008, p. 1-3.

Research output: Contribution to journalArticle

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