A Helicobacter pylori eradikációjának sikertelensége

szempontok a további kezelés megítéléséhez.

Translated title of the contribution: Failure of Helicobacter pylori eradication--suggestions for further therapy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Success of first H. pylori eradication attempts in the literature is around 80-90% and based on urea breath test of 1027 patients in Hungary is 75%. Repeated eradication attempts are needed in 10-25% of cases. In the clinical practice in Hungary second and third eradication attempts were successful only in 36% and 20% of cases. To improve efficacy the following suggestions has to be kept in mind: 1. Do not repeat the same combination if the first attempt is failed. 2. After failure of the first PPI + amoxicillin + clarithromycin triple therapy, either the quadriple therapy (PPI + tetracycline + metronidazole + bismuth) or the replacement of PPI with ranitidine bismuth citrate in the triple therapy is suggested. 3. If PPI + amoxicillin + metronidazole/tinidazole therapy fails, the metronidazole/tinidazole can be replaced by clarythromycin. 4. Do not start with clarithromycin + metronidazole/tinidazole therapy. 5. In case of uncertain previous therapies and for third eradication treatment send the patient to specialist. Rifabutin-based combinations seem to be effective, but the use of them in general practice is not advised due to the possible development of mycobacterium tuberculosis resistance.

Original languageHungarian
Pages (from-to)1299-1302
Number of pages4
JournalOrvosi Hetilap
Volume144
Issue number26
Publication statusPublished - Jun 29 2003

Fingerprint

Helicobacter pylori
Metronidazole
Tinidazole
Clarithromycin
Hungary
Amoxicillin
Therapeutics
Rifabutin
Bismuth
Breath Tests
Tetracycline
Mycobacterium tuberculosis
General Practice
Urea

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A Helicobacter pylori eradikációjának sikertelensége : szempontok a további kezelés megítéléséhez. / Prónai, L.; Tulassay, Z.

In: Orvosi Hetilap, Vol. 144, No. 26, 29.06.2003, p. 1299-1302.

Research output: Contribution to journalArticle

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