Failure of exogenous ATP and creatine phosphate to modify the course of E coli endotoxin shock in the cat.

D. J. McCaig, J. Parratt

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Exogenous adenosine triphosphate (ATP) (in combination with MgCl2) and also creatine phosphate (CrP), have been administered intravenously to endotoxin-shocked cats. Untreated shocked cats exhibited systemic hypotension during the first hour and again from four hours. Cardiac output fell progressively, and markedly elevated arterial lactate levels were evident within one hour of endotoxin administration. Treatment with ATP (10 mg/kg every 30 minutes) during shock led to rapid hemodynamic deterioration in all cats; most of the cats were dead before completion of dosing (at three hours). Long-lasting systemic hypotension and bradycardia were associated with this ATP administration and marked hypoglycemia developed in the survivors. Neither ATP (62 mg/kg) administered before endotoxin, nor CrP (500 mg/kg; administered either prior to endotoxin, or one hour afterwards) significantly modified the hemodynamic or metabolic changes associated with endotoxin shock in this species. Neither ATP nor CrP increased survival (assessed at five hours). Other workers have demonstrated improved survival from shock with ATP treatment. There may be species differences in the responsiveness to exogenous ATP or, alternatively, a difference in the role of high-energy phosphates in different types of shock.

Original languageEnglish
Pages (from-to)235-244
Number of pages10
JournalCirculatory Shock
Volume6
Issue number3
Publication statusPublished - 1979

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Phosphocreatine
Adenine Nucleotides
Endotoxins
Shock
Cats
Adenosine Triphosphate
Escherichia coli
Hypotension
Hemodynamics
Magnesium Chloride
Bradycardia
Hypoglycemia
Cardiac Output
Lactic Acid
Phosphates

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Failure of exogenous ATP and creatine phosphate to modify the course of E coli endotoxin shock in the cat. / McCaig, D. J.; Parratt, J.

In: Circulatory Shock, Vol. 6, No. 3, 1979, p. 235-244.

Research output: Contribution to journalArticle

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