Faecal microbiota transplantation for Clostridium difficile infection using a lyophilized inoculum from non-related donors

A case series involving 19 patients

Szabolcs Vigvári, Dávid Sipos, Jenő Solt, A. Vincze, Béla Kocsis, Zsuzsanna Nemes, Ágnes Kappéter, Zsófia Feiszt, Beáta Kovács, Zoltán Péterfi

Research output: Contribution to journalArticle

Abstract

Faecal microbiota transplantation (FMT) has been reported to be effective in treating relapsing of refractory Clostridium difficile infections, although some practical barriers are limiting its widespread use. In this study, our objective was to evaluate the rate of resolution of diarrhea following administration of lyophilized and resolved FMT via a nasogastric (NG) tube. We recruited 19 patients suffered from laboratory-confirmed C. difficile infection. Each of them was treated by lyophilized and resolved inoculum through a NG tube. One participant succumbed following the procedure due to unrelated diseases. Out of 18 cases, 15 patients reportedly experienced a resolution of the symptoms. One patient was treated with another course of antibiotics, and two of the non-responders were successfully retreated with another course of FMT utilizing a lyophilized inoculum. Notably, no significant adverse activities were observed. In accordance to our clinical experiences, a patient will likely benefit from FMT treatment including lyophilized inoculum.

Original languageEnglish
Pages (from-to)69-78
Number of pages10
JournalActa microbiologica et immunologica Hungarica
Volume66
Issue number1
DOIs
Publication statusPublished - Mar 1 2019

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Clostridium Infections
Clostridium difficile
Tissue Donors
Diarrhea
Anti-Bacterial Agents
Fecal Microbiota Transplantation

Keywords

  • infection
  • faecal microbiota transplantation
  • lyophilization
  • nasogastric tube

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Faecal microbiota transplantation for Clostridium difficile infection using a lyophilized inoculum from non-related donors : A case series involving 19 patients. / Vigvári, Szabolcs; Sipos, Dávid; Solt, Jenő; Vincze, A.; Kocsis, Béla; Nemes, Zsuzsanna; Kappéter, Ágnes; Feiszt, Zsófia; Kovács, Beáta; Péterfi, Zoltán.

In: Acta microbiologica et immunologica Hungarica, Vol. 66, No. 1, 01.03.2019, p. 69-78.

Research output: Contribution to journalArticle

Vigvári, Szabolcs ; Sipos, Dávid ; Solt, Jenő ; Vincze, A. ; Kocsis, Béla ; Nemes, Zsuzsanna ; Kappéter, Ágnes ; Feiszt, Zsófia ; Kovács, Beáta ; Péterfi, Zoltán. / Faecal microbiota transplantation for Clostridium difficile infection using a lyophilized inoculum from non-related donors : A case series involving 19 patients. In: Acta microbiologica et immunologica Hungarica. 2019 ; Vol. 66, No. 1. pp. 69-78.
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