Faecal matrix metalloprotease-9 is a more sensitive marker for diagnosing pouchitis than faecal calprotectin: Results from a pilot study

Klaudia Farkas, Anita Bálint, Renáta Bor, Imre Földesi, Mónika Szucs, Ferenc Nagy, Zoltán Szepes, Anita Annaházi, Richárd Róka, Tamás Molnár

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Background: Potential non-invasive markers of pouchitis would have a great deal of significance within clinical practice. Aim: This study is aimed at assessing the diagnostic accuracy of fecal calprotectin and matrix metalloprotease-9 as potential markers in patients both with and without pouchitis. Patients and methods: Stool and blood samples were collected from 33 ileal pouch-anal anastomosis patients before a follow-up pouchoscopy. Biopsy samples were taken for histological purposes. The presence of cuffitis and stenosis was evaluated with an endoscopy. Calprotectin and matrix metalloprotease-9 were quantified with an enzyme-linked immunosorbent assay. Results: Pouchitis was detected in 30.3% of the patients. The levels of fecal calprotectin and matrix metalloprotease-9 increased significantly in patients with pouchitis. The sensitivity and specificity of matrix metalloprotease-9 was higher than that of fecal calprotectin. Only matrix metalloprotease-9 correlated significantly with the severity of pouchitis. Discussion: Fecal matrix metalloprotease-9 has a high specificity in the diagnosis of pouchitis.

Original languageEnglish
Pages (from-to)387-392
Number of pages6
JournalExpert Review of Gastroenterology and Hepatology
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

Keywords

  • fecal calprotectin
  • ileal pouch-anal anastomosis
  • matrix metalloprotease-9
  • pouchitis
  • ulcerative colitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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