Faecal matrix metalloprotease-9 is a more sensitive marker for diagnosing pouchitis than faecal calprotectin

Results from a pilot study

Klaudia Farkas, Anita Bálint, Renáta Bor, I. Földesi, Mónika Szucs, F. Nagy, Zoltán Szepes, Anita Annaházi, R. Róka, T. Molnár

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Potential non-invasive markers of pouchitis would have a great deal of significance within clinical practice. Aim: This study is aimed at assessing the diagnostic accuracy of fecal calprotectin and matrix metalloprotease-9 as potential markers in patients both with and without pouchitis. Patients and methods: Stool and blood samples were collected from 33 ileal pouch-anal anastomosis patients before a follow-up pouchoscopy. Biopsy samples were taken for histological purposes. The presence of cuffitis and stenosis was evaluated with an endoscopy. Calprotectin and matrix metalloprotease-9 were quantified with an enzyme-linked immunosorbent assay. Results: Pouchitis was detected in 30.3% of the patients. The levels of fecal calprotectin and matrix metalloprotease-9 increased significantly in patients with pouchitis. The sensitivity and specificity of matrix metalloprotease-9 was higher than that of fecal calprotectin. Only matrix metalloprotease-9 correlated significantly with the severity of pouchitis. Discussion: Fecal matrix metalloprotease-9 has a high specificity in the diagnosis of pouchitis.

Original languageEnglish
Pages (from-to)387-392
Number of pages6
JournalExpert Review of Gastroenterology and Hepatology
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

Fingerprint

Pouchitis
Leukocyte L1 Antigen Complex
Metalloproteases
Colonic Pouches
Endoscopy
Pathologic Constriction
Enzyme-Linked Immunosorbent Assay
Biopsy
Sensitivity and Specificity

Keywords

  • fecal calprotectin
  • ileal pouch-anal anastomosis
  • matrix metalloprotease-9
  • pouchitis
  • ulcerative colitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Faecal matrix metalloprotease-9 is a more sensitive marker for diagnosing pouchitis than faecal calprotectin : Results from a pilot study. / Farkas, Klaudia; Bálint, Anita; Bor, Renáta; Földesi, I.; Szucs, Mónika; Nagy, F.; Szepes, Zoltán; Annaházi, Anita; Róka, R.; Molnár, T.

In: Expert Review of Gastroenterology and Hepatology, Vol. 9, No. 3, 01.03.2015, p. 387-392.

Research output: Contribution to journalArticle

@article{c08bb0a384934dc69b7fc6cbdb614c47,
title = "Faecal matrix metalloprotease-9 is a more sensitive marker for diagnosing pouchitis than faecal calprotectin: Results from a pilot study",
abstract = "Background: Potential non-invasive markers of pouchitis would have a great deal of significance within clinical practice. Aim: This study is aimed at assessing the diagnostic accuracy of fecal calprotectin and matrix metalloprotease-9 as potential markers in patients both with and without pouchitis. Patients and methods: Stool and blood samples were collected from 33 ileal pouch-anal anastomosis patients before a follow-up pouchoscopy. Biopsy samples were taken for histological purposes. The presence of cuffitis and stenosis was evaluated with an endoscopy. Calprotectin and matrix metalloprotease-9 were quantified with an enzyme-linked immunosorbent assay. Results: Pouchitis was detected in 30.3{\%} of the patients. The levels of fecal calprotectin and matrix metalloprotease-9 increased significantly in patients with pouchitis. The sensitivity and specificity of matrix metalloprotease-9 was higher than that of fecal calprotectin. Only matrix metalloprotease-9 correlated significantly with the severity of pouchitis. Discussion: Fecal matrix metalloprotease-9 has a high specificity in the diagnosis of pouchitis.",
keywords = "fecal calprotectin, ileal pouch-anal anastomosis, matrix metalloprotease-9, pouchitis, ulcerative colitis",
author = "Klaudia Farkas and Anita B{\'a}lint and Ren{\'a}ta Bor and I. F{\"o}ldesi and M{\'o}nika Szucs and F. Nagy and Zolt{\'a}n Szepes and Anita Annah{\'a}zi and R. R{\'o}ka and T. Moln{\'a}r",
year = "2015",
month = "3",
day = "1",
doi = "10.1586/17474124.2015.965144",
language = "English",
volume = "9",
pages = "387--392",
journal = "Expert Review of Gastroenterology and Hepatology",
issn = "1747-4124",
publisher = "Expert Reviews Ltd.",
number = "3",

}

TY - JOUR

T1 - Faecal matrix metalloprotease-9 is a more sensitive marker for diagnosing pouchitis than faecal calprotectin

T2 - Results from a pilot study

AU - Farkas, Klaudia

AU - Bálint, Anita

AU - Bor, Renáta

AU - Földesi, I.

AU - Szucs, Mónika

AU - Nagy, F.

AU - Szepes, Zoltán

AU - Annaházi, Anita

AU - Róka, R.

AU - Molnár, T.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background: Potential non-invasive markers of pouchitis would have a great deal of significance within clinical practice. Aim: This study is aimed at assessing the diagnostic accuracy of fecal calprotectin and matrix metalloprotease-9 as potential markers in patients both with and without pouchitis. Patients and methods: Stool and blood samples were collected from 33 ileal pouch-anal anastomosis patients before a follow-up pouchoscopy. Biopsy samples were taken for histological purposes. The presence of cuffitis and stenosis was evaluated with an endoscopy. Calprotectin and matrix metalloprotease-9 were quantified with an enzyme-linked immunosorbent assay. Results: Pouchitis was detected in 30.3% of the patients. The levels of fecal calprotectin and matrix metalloprotease-9 increased significantly in patients with pouchitis. The sensitivity and specificity of matrix metalloprotease-9 was higher than that of fecal calprotectin. Only matrix metalloprotease-9 correlated significantly with the severity of pouchitis. Discussion: Fecal matrix metalloprotease-9 has a high specificity in the diagnosis of pouchitis.

AB - Background: Potential non-invasive markers of pouchitis would have a great deal of significance within clinical practice. Aim: This study is aimed at assessing the diagnostic accuracy of fecal calprotectin and matrix metalloprotease-9 as potential markers in patients both with and without pouchitis. Patients and methods: Stool and blood samples were collected from 33 ileal pouch-anal anastomosis patients before a follow-up pouchoscopy. Biopsy samples were taken for histological purposes. The presence of cuffitis and stenosis was evaluated with an endoscopy. Calprotectin and matrix metalloprotease-9 were quantified with an enzyme-linked immunosorbent assay. Results: Pouchitis was detected in 30.3% of the patients. The levels of fecal calprotectin and matrix metalloprotease-9 increased significantly in patients with pouchitis. The sensitivity and specificity of matrix metalloprotease-9 was higher than that of fecal calprotectin. Only matrix metalloprotease-9 correlated significantly with the severity of pouchitis. Discussion: Fecal matrix metalloprotease-9 has a high specificity in the diagnosis of pouchitis.

KW - fecal calprotectin

KW - ileal pouch-anal anastomosis

KW - matrix metalloprotease-9

KW - pouchitis

KW - ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=84923266203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923266203&partnerID=8YFLogxK

U2 - 10.1586/17474124.2015.965144

DO - 10.1586/17474124.2015.965144

M3 - Article

VL - 9

SP - 387

EP - 392

JO - Expert Review of Gastroenterology and Hepatology

JF - Expert Review of Gastroenterology and Hepatology

SN - 1747-4124

IS - 3

ER -