Facts and challenges in the understanding of the biosynthesis of peptaibols by Trichoderma

Christian P. Kubicek, Monika Komoń-Zelazowska, Erzsébet Sándor, Irina S. Druzhinina

Research output: Contribution to journalReview article

31 Citations (Scopus)


Species of the mitosporic filamentous fungal genus Trichoderma are prominent producers of both short (7-11 residues) and long (18-20 residues) peptaibols and peptaibiotics, which are thought to be involved in their interaction with other living systems. Numerous reviews are available regarding biodiversity, structure, and mode of action of these peptide derivatives, but little emphasis has been paid to the physiology and genetics of their formation. In this review article, we used the recent knowledge on biosynthesis and production of these components to speculate on some of the unknown points. We also highlight areas where further research is most urgently needed.

Original languageEnglish
Pages (from-to)1068-1082
Number of pages15
JournalChemistry and Biodiversity
Issue number6
Publication statusPublished - Jul 24 2007


ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

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