Factors of the extrinsic pathway of blood coagulation in fetal placental macrophages

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3 Citations (Scopus)

Abstract

Term human placentae were examined to identify and localize the factors contributing to extravascular fibrin formation. In addition to blood vessels, components of the extrinsic coagulation cascade were also demonstrated in intracellular localization. These cells in double and treble labeling systems expressed macrophage marker antigens, recognized by DAKO antimacrophage, RFD7, Amersham antimacrophage, and KiM7 monoclonal antibodies and showed positivity for alpha-naphthyl-acetate-esterase (ANAE). The fact that factors of the extrinsic coagulation system can be demonstrated in fetal macrophages of the chorionic stroma suggests that their role is not restricted to cellular defense and phagocytosis, but they may be involved in extravascular intraplacental fibrin formation as well.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalAmerican Journal of Reproductive Immunology
Volume21
Issue number2
Publication statusPublished - 1989

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Blood Coagulation
Fibrin
Macrophages
Naphthol AS D Esterase
Blood Coagulation Factors
Differentiation Antigens
Phagocytosis
Placenta
Blood Vessels
Monoclonal Antibodies

Keywords

  • Clotting factors
  • Endothelial cells
  • Fetal macrophages
  • Maternal macrophages

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynaecology

Cite this

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title = "Factors of the extrinsic pathway of blood coagulation in fetal placental macrophages",
abstract = "Term human placentae were examined to identify and localize the factors contributing to extravascular fibrin formation. In addition to blood vessels, components of the extrinsic coagulation cascade were also demonstrated in intracellular localization. These cells in double and treble labeling systems expressed macrophage marker antigens, recognized by DAKO antimacrophage, RFD7, Amersham antimacrophage, and KiM7 monoclonal antibodies and showed positivity for alpha-naphthyl-acetate-esterase (ANAE). The fact that factors of the extrinsic coagulation system can be demonstrated in fetal macrophages of the chorionic stroma suggests that their role is not restricted to cellular defense and phagocytosis, but they may be involved in extravascular intraplacental fibrin formation as well.",
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T1 - Factors of the extrinsic pathway of blood coagulation in fetal placental macrophages

AU - Kappelmayer, J.

AU - Ádány, R.

PY - 1989

Y1 - 1989

N2 - Term human placentae were examined to identify and localize the factors contributing to extravascular fibrin formation. In addition to blood vessels, components of the extrinsic coagulation cascade were also demonstrated in intracellular localization. These cells in double and treble labeling systems expressed macrophage marker antigens, recognized by DAKO antimacrophage, RFD7, Amersham antimacrophage, and KiM7 monoclonal antibodies and showed positivity for alpha-naphthyl-acetate-esterase (ANAE). The fact that factors of the extrinsic coagulation system can be demonstrated in fetal macrophages of the chorionic stroma suggests that their role is not restricted to cellular defense and phagocytosis, but they may be involved in extravascular intraplacental fibrin formation as well.

AB - Term human placentae were examined to identify and localize the factors contributing to extravascular fibrin formation. In addition to blood vessels, components of the extrinsic coagulation cascade were also demonstrated in intracellular localization. These cells in double and treble labeling systems expressed macrophage marker antigens, recognized by DAKO antimacrophage, RFD7, Amersham antimacrophage, and KiM7 monoclonal antibodies and showed positivity for alpha-naphthyl-acetate-esterase (ANAE). The fact that factors of the extrinsic coagulation system can be demonstrated in fetal macrophages of the chorionic stroma suggests that their role is not restricted to cellular defense and phagocytosis, but they may be involved in extravascular intraplacental fibrin formation as well.

KW - Clotting factors

KW - Endothelial cells

KW - Fetal macrophages

KW - Maternal macrophages

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