Factors derived from adrenals are required for activation of cardiac gene expression in angiotensin II-induced hypertension

G. Földes, M. Suo, I. Szokodi, Z. Lakó-Futó, R. Dechâtel, O. Vuolteenaho, P. Huttunen, H. Ruskoaho, M. Tóth

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Abstract

The mechanisms mediating the activation of cardiac gene expression during pressure overload are not fully understood. We examined whether angiotensin II-induced activation of ventricular gene expression is related to blood pressure and ventricular mass or requires other factors by infusing angiotensin II in sham-operated and adrenalectomized rats. In sham-operated rats, angiotensin II (33 μg/kg·h, sc) produced a significant increase in mean arterial pressure (measured by telemetry) within 3 h. Mean arterial pressure (up to 45 h) and the increase in left ventricular hypertrophy in adrenalectomized rats during angiotensin II infusion were similar to those in sham-operated rats. Angiotensin II produced 3.6-fold (P < 0.01) and 20.4-fold (P < 0.001) increases in ventricular atrial natriuretic peptide mRNA levels at 12 and 72 h, respectively. Angiotensin II infusion for 12 h also significantly increased the ventricular mRNA levels of B-type natriuretic peptide (5.2-fold) and adrenomedullin (1.4-fold). Adrenalectomy either abolished (atrial natriuretic peptide and adrenomedullin) or blunted (B-type natriuretic peptide) the early activation of ventricular gene expression by angiotensin II. The baseline synthesis of atrial natriuretic peptide, B-type natriuretic peptide, and adrenomedullin in the ventricle remained unchanged in adrenalectomized rats. In conclusion, our results indicate that factors derived from the adrenals are required for angiotensin II-induced early activation of cardiac gene expression.

Original languageEnglish
Pages (from-to)4256-4263
Number of pages8
JournalEndocrinology
Volume142
Issue number10
DOIs
Publication statusPublished - Jan 1 2001

ASJC Scopus subject areas

  • Endocrinology

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    Földes, G., Suo, M., Szokodi, I., Lakó-Futó, Z., Dechâtel, R., Vuolteenaho, O., Huttunen, P., Ruskoaho, H., & Tóth, M. (2001). Factors derived from adrenals are required for activation of cardiac gene expression in angiotensin II-induced hypertension. Endocrinology, 142(10), 4256-4263. https://doi.org/10.1210/endo.142.10.8421