Factors affecting sensitivity and specificity of a diagnostic test: the exercise thallium scintigram

Robert Detrano, A. Jánosi, Kenneth P. Lyons, Gilberto Marcondes, Nabil Abbassi, Victor F. Froelicher

Research output: Contribution to journalArticle

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Abstract

Technical and methodological factors might affect the reported accuracies of diagnostic tests. To assess their influence on the accuracy of exercise thallium scintigraphy, the medical literature (1977 to 1986) was non-selectively searched and meta-analysis was applied to the 56 publications thus retrieved. These were analyzed for year of publication, sex and mean age of patients, percentage of patients with angina pectoris, percentage of patients with prior myocardial infarction, percentage of patients taking beta-blocking medications, and for angio-graphic referral (workup) bias, blinding of tests, and technical factors. The percentage of patients with myocardial infarction had the highest correlation with sensitivity (0.45, p = 0.0007). Only the inclusion of subjects with prior infarction and the percentage of men in the study group were independently and significantly (p

Original languageEnglish
Pages (from-to)699-710
Number of pages12
JournalThe American Journal of Medicine
Volume84
Issue number4
DOIs
Publication statusPublished - 1988

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Thallium
Routine Diagnostic Tests
Exercise
Sensitivity and Specificity
Publications
Myocardial Infarction
Angina Pectoris
Radionuclide Imaging
Infarction
Meta-Analysis
Referral and Consultation

ASJC Scopus subject areas

  • Nursing(all)

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Factors affecting sensitivity and specificity of a diagnostic test : the exercise thallium scintigram. / Detrano, Robert; Jánosi, A.; Lyons, Kenneth P.; Marcondes, Gilberto; Abbassi, Nabil; Froelicher, Victor F.

In: The American Journal of Medicine, Vol. 84, No. 4, 1988, p. 699-710.

Research output: Contribution to journalArticle

Detrano, Robert ; Jánosi, A. ; Lyons, Kenneth P. ; Marcondes, Gilberto ; Abbassi, Nabil ; Froelicher, Victor F. / Factors affecting sensitivity and specificity of a diagnostic test : the exercise thallium scintigram. In: The American Journal of Medicine. 1988 ; Vol. 84, No. 4. pp. 699-710.
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