Factor XIIIa as a nerve-associated transglutaminase

Alon Monsonego, Tal Mizrahi, Shoshana Eitan, Gila Moalem, H. Bárdos, R. Ádány, Michal Schwartz

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Recent findings have led to changes in the traditional concept of nerve recovery, including the realization that injured nerves, like any other injured tissue, need the assistance of blood-derived cells and factors in order to heal. We show that factor XIIIa (FXIIIa, the potentially active a2- subunit of factor XIII), an enzyme that participates in blood coagulation by stabilizing the fibrin clot, is also active in the nervous system where it may play a key role in the healing of injured tissue. We demonstrate that the plasma, macrophages and nerves of fish contain a 55 kDa form of transglutaminase that cross-reacts immunologically with the a-subunit of FXIII in mammals (80 kDa). The fish enzyme in the plasma, unlike its mammalian counterpart, is active, pointing to a difference in control of the coagulation pathway in the two species. Analysis of FXIIIa expression in mammalian neural tissues and their response to injury revealed high levels of the enzyme in media conditioned by peripheral nerves as compared with medium conditioned by nerves of the central nervous system. Furthermore, similarity was observed in the postinjury behavior of FXIIIa in regenerating nerve tissues (peripheral nervous system of mammals and the central nervous system of fish). We suggest that the postinjury level of factor XIIIa in the nervous system may be related to the tissue's regenerative capacity, and that FXIIIa may therefore be a link underlying a possible association between the processes of blood coagulation and nerve healing.

Original languageEnglish
Pages (from-to)1163-1171
Number of pages9
JournalFASEB Journal
Volume12
Issue number12
Publication statusPublished - 1998

Fingerprint

Factor XIIIa
Transglutaminases
protein-glutamine gamma-glutamyltransferase
Neurology
nerve tissue
Tissue
Fishes
Coagulation
Fish
Blood Coagulation
Conditioned Culture Medium
Blood
Mammals
Nervous System
Enzymes
Central Nervous System
blood coagulation
Factor XIII
Nerve Tissue
nervous system

Keywords

  • CNS
  • FXIIIa
  • Nerve regeneration
  • PNS
  • Thrombin

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Monsonego, A., Mizrahi, T., Eitan, S., Moalem, G., Bárdos, H., Ádány, R., & Schwartz, M. (1998). Factor XIIIa as a nerve-associated transglutaminase. FASEB Journal, 12(12), 1163-1171.

Factor XIIIa as a nerve-associated transglutaminase. / Monsonego, Alon; Mizrahi, Tal; Eitan, Shoshana; Moalem, Gila; Bárdos, H.; Ádány, R.; Schwartz, Michal.

In: FASEB Journal, Vol. 12, No. 12, 1998, p. 1163-1171.

Research output: Contribution to journalArticle

Monsonego, A, Mizrahi, T, Eitan, S, Moalem, G, Bárdos, H, Ádány, R & Schwartz, M 1998, 'Factor XIIIa as a nerve-associated transglutaminase', FASEB Journal, vol. 12, no. 12, pp. 1163-1171.
Monsonego A, Mizrahi T, Eitan S, Moalem G, Bárdos H, Ádány R et al. Factor XIIIa as a nerve-associated transglutaminase. FASEB Journal. 1998;12(12):1163-1171.
Monsonego, Alon ; Mizrahi, Tal ; Eitan, Shoshana ; Moalem, Gila ; Bárdos, H. ; Ádány, R. ; Schwartz, Michal. / Factor XIIIa as a nerve-associated transglutaminase. In: FASEB Journal. 1998 ; Vol. 12, No. 12. pp. 1163-1171.
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