Factor V Leiden and apolipoprotein E genotypes in severe femoropopliteal atherosclerosis with restenosis

Gábor Vallus, Béla Dlustus, György Acsády, Zoltán Papp, Judit Skopál, Zoltán Nagy, Zoltán Prohászka, László Romics, István Karádi, Bálint Nagy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The role of factor V (Leiden) mutation, thrombophilia, and apolipoprotein E (apoE) alleles in the pathogenesis of accelerated atherosclerosis and restenosis was studied in patients requiring reoperation within five years after femoropopliteal angioplasty with artificial grafts. Methods: One hundred ninety-eight consecutive patients with femoropopliteal atherosclerotic disease, reoperated for restenosis were contacted by phone and 100 of them returned for laboratory and clinical work-up. In addition to clinical evaluation and routine laboratory investigations, parameters of lipoprotein metabolism, factor V (Leiden) mutation and apolipoprotein E (apoE) allele were studied by PCR amplification of DNA and endonuclease digestion techniques. Results: A significantly higher incidence of factor V (Leiden) mutation was found in patients with atherosclerosis and restenosis, compared to 445 healthy blood donors (13/200, 6.5% vs. 34/890, 3.8%, p = 0.0379). Distribution of the alleles of the apolipoprotein E (apoE) gene was different, when the patients were compared to 372 controls; however, the difference only approached the level of statistical significance (25/200, 12.5% vs. 56/744, 7.5%, p = 0.0515). Comparing the two groups, the number of ε4 allele carriers was significantly higher among patients with restenosis (25/100, 25% vs. 53/272, 14%, p = 0.0147). Conclusion: Factor V (Leiden) mutation may influence the progression of atherosclerosis and the development of restenosis after revascularization in patients with accelerated femoropopliteal atherosclerosis. Further investigation is needed whether long-term anticoagulation has an impact or not on the course of disease in such cases. ApoE ε4 allele should be screened in patients with femoropopliteal atherosclerosis, because it indicates a faster progression of atherosclerosis and may predict restenosis after revascularization procedure.

Original languageEnglish
Pages (from-to)256-260
Number of pages5
JournalClinica Chimica Acta
Volume377
Issue number1-2
DOIs
Publication statusPublished - Feb 2 2007

Keywords

  • Apolipoprotein E genotype
  • Arteficial graft
  • Factor V (Leiden)
  • Femoropopliteal atherosclerosis and restenosis
  • Lipoprotein

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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