Facilitation of memory consolidation by vasopressin: Mediation by terminals of the dorsal noradrenergic bundle?

G. Kovács, Béla Bohus, Dirk H G Versteeg

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Administration of arginine-vasopressin (AVP, 5 μ, s.c.) immediately after the learning trial results in a long-term facilitation of a one-trial learning passive avoidance response. This effect of AVP is absent in animals with prior destruction of the ascending dorsal noradrenergic bundle by bilateral microinjection of 6-hydroxy-dopamine (6-OHDA). Postlearning local microinjection of a minute amount of AVP via chronically implanted cannulae into the locus coeruleus did not influence passive avoidance behavior. Upon injection into the midbrain dorsal raphe nucleus, however AVP facilitated passive avoidance behavior. This effect, however, was absent in rats receiving previous microinjection of 5,6-dihydroxytryptamine (5,6-DHT) or of 6-OHDA into the dorsal raphe nucleus. Bilateral 6-OHDA-induced lesions of the nucleus accumbens or 5,6-DHT-induced destruction of the dorsal raphe nucleus did not prevent the effect of AVP administered subcutaneously. The data suggest that vasopressin facilitates memory consolidation processes by modulating noradrenergic neurotransmission in terminals of the dorsal noradrenergic bundle. The serotoninergic neuronal network originating from the dorsal raphe nucleus has a secondary-norepinephrine-mediated-influence upon these processes.

Original languageEnglish
Pages (from-to)73-85
Number of pages13
JournalBrain Research
Volume172
Issue number1
DOIs
Publication statusPublished - Aug 17 1979

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Avoidance Learning
Vasopressins
Oxidopamine
Microinjections
5,6-Dihydroxytryptamine
Locus Coeruleus
Arginine Vasopressin
Nucleus Accumbens
Synaptic Transmission
Dopamine
Norepinephrine
Learning
Injections
Memory Consolidation
Dorsal Raphe Nucleus

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Facilitation of memory consolidation by vasopressin : Mediation by terminals of the dorsal noradrenergic bundle? / Kovács, G.; Bohus, Béla; Versteeg, Dirk H G.

In: Brain Research, Vol. 172, No. 1, 17.08.1979, p. 73-85.

Research output: Contribution to journalArticle

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