Facilitated column selection in reversed-phase liquid chromatography for pharmaceutical separations

Erik Haghedooren, Dóra Visky, Pieter Dehouck, Kristóf Kóczián, José Diana, Zsuzsanna Kovács, Béla Noszál, Jos Hoogmartens, Erwin Adams

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11 Citations (Scopus)

Abstract

This article gives an overview of the performance of a previously developed system for the ranking of C18 reversed-phase columns applied to different pharmaceutical analyses. The separation of eight different drug substances from their respective impurities was studied. The chromatographic procedure for acetylsalicylic acid, clindamycin hydrochloride, buflomedil hydrochloride, chloramphenicol sodium succinate, Phenoxymethylpenicillin and nimesulide was performed according to the corresponding European Pharmacopoeia monograph. The separations of dihydrostreptomycin sulphate and vancomycin were performed according to literature. It was found that that the column ranking system is a helpful tool in the selection of suitable columns in these analyses.

Original languageEnglish
Pages (from-to)82-96
Number of pages15
JournalLC GC Europe
Volume20
Issue number2
Publication statusPublished - Feb 2007

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ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Haghedooren, E., Visky, D., Dehouck, P., Kóczián, K., Diana, J., Kovács, Z., Noszál, B., Hoogmartens, J., & Adams, E. (2007). Facilitated column selection in reversed-phase liquid chromatography for pharmaceutical separations. LC GC Europe, 20(2), 82-96.