Facilitated column selection in pharmaceutical analyses using a simple column classification system

Dóra Visky, Erik Haghedooren, Pieter Dehouck, Zsuzsanna Kovács, Kristof Kóczián, B. Noszál, Jos Hoogmartens, Erwin Adams

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

In this paper, the performance of a previously developed classification system applied to pharmaceutical chromatographic analyses, is investigated. The separation of seven different drug substances from their respective impurities was studied. The chromatographic procedure for acetylsalicylic acid, clindamycin hydrochloride, buflomedil hydrochloride, chloramphenicol sodium succinate, nimesulide and phenoxymethylpenicillin was performed according to the corresponding European Pharmacopoeia (Ph. Eur.) monograph. The separation of dihydrostreptomycin sulphate was performed according to the literature. It is shown that the column ranking system is a helpful tool in the selection of a suitable column in these analyses.

Original languageEnglish
Pages (from-to)103-114
Number of pages12
JournalJournal of Chromatography A
Volume1101
Issue number1-2
DOIs
Publication statusPublished - Jan 6 2006

Fingerprint

nimesulide
Dihydrostreptomycin Sulfate
Penicillin V
Pharmacopoeias
Clindamycin
Pharmaceutical Preparations
Aspirin
Chromatography
Impurities
buflomedil
chloramphenicol succinate

Keywords

  • Chromatographic tests
  • Column characterisation
  • Column classification

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Facilitated column selection in pharmaceutical analyses using a simple column classification system. / Visky, Dóra; Haghedooren, Erik; Dehouck, Pieter; Kovács, Zsuzsanna; Kóczián, Kristof; Noszál, B.; Hoogmartens, Jos; Adams, Erwin.

In: Journal of Chromatography A, Vol. 1101, No. 1-2, 06.01.2006, p. 103-114.

Research output: Contribution to journalArticle

Visky, D, Haghedooren, E, Dehouck, P, Kovács, Z, Kóczián, K, Noszál, B, Hoogmartens, J & Adams, E 2006, 'Facilitated column selection in pharmaceutical analyses using a simple column classification system', Journal of Chromatography A, vol. 1101, no. 1-2, pp. 103-114. https://doi.org/10.1016/j.chroma.2005.09.069
Visky, Dóra ; Haghedooren, Erik ; Dehouck, Pieter ; Kovács, Zsuzsanna ; Kóczián, Kristof ; Noszál, B. ; Hoogmartens, Jos ; Adams, Erwin. / Facilitated column selection in pharmaceutical analyses using a simple column classification system. In: Journal of Chromatography A. 2006 ; Vol. 1101, No. 1-2. pp. 103-114.
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