Facile synthesis of unsymmetrical 1,n′-disubstituted ferrocenoyl amino acid derivatives by palladium-catalyzed aminocarbonylation

Árpád Kuik, Rita Skoda-Földes, László Jánosi, László Kollár

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Abstract

Various unsymmetrical 1,n′-disubstituted ferrocenoyl amino acids were obtained by palladium-catalyzed aminocarbonylation starting from 1,1′-diiodoferrocene. The reactions were carried out in one-pot, using an equimolar mixture of two amino acid esters as nucleophiles. The structures of the products were determined by 1H NMR, 13C NMR, IR and MS analyses. Each was found to adopt an ordered, intramolecularly hydrogen bonded conformation.

Original languageEnglish
Pages (from-to)1456-1458
Number of pages3
JournalSynthesis
Issue number10
DOIs
Publication statusPublished - May 16 2007

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Keywords

  • Amino acids
  • Carbonylations
  • Ferrocene
  • Homogeneous catalysis
  • Palladium

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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