Facile synthesis of steroidal vicinal hydroxysulfides via the reaction of steroidal epoxides with thiols in the presence of an ionic liquid

Anita Horváth, David Frigyes, Sándor Mahó, Zoltán Berente, László Kollár, Rita Skoda-Földes

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Ring-opening of steroidal 2,3-epoxides with thiols can be carried out effectively in the Brønsted acidic ionic liquid [Hmim] +[BF4]- as a recyclable solvent and catalyst. The use of other ionic liquids/molten salts resulted in a decrease in the conversion and/or in reduced selectivity. In [bmim]+Br-, a conversion of 2,3epoxy-17-ones into 2,17- and 3,17-diones was also observed.

Original languageEnglish
Article numberT07909SS
Pages (from-to)4037-4041
Number of pages5
JournalSynthesis
Issue number23
DOIs
Publication statusPublished - Dec 1 2009

    Fingerprint

Keywords

  • Catalysis
  • Epoxides
  • Ionic liquids
  • Ring-opening
  • Steroids
  • Thiols

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

Cite this