Facile synthesis of steroidal phenyl ketones via homogeneous catalytic carbonylation

Rita Skoda-Földes, Zoltán Székvölgyi, László Kollár, Zoltán Berente, Judit Horváth, Zoltán Tuba

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Steroidal phenyl ketones were synthesised in high yields by palladium- catalysed carbonylation reactions of 17-iodo-androst-16-ene derivatives in the presence of NaBPh4 under mild reaction conditions. Alkenyl bromides or enol triflates gave lower yields in the same reaction. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)3415-3418
Number of pages4
JournalTetrahedron
Volume56
Issue number21
DOIs
Publication statusPublished - May 19 2000

Keywords

  • Carbonylation
  • Pd-catalysis
  • Phenyl ketones
  • Steroids

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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