Facile synthesis of 17-formyl steroids via palladium-catalyzed homogeneous carbonylation reaction

Andrea Petz, Judit Horváth, Zoltán Tuba, Zoltán Pintér, L. Kollár

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

17-Formyl-androst-16-ene and its analogues were synthesized from the corresponding 17-iodo-16-ene derivatives in palladium-catalyzed formylation reaction using tributyltin hydride as hydrogen source under mild reaction conditions. The formation of androst-16-ene and its isomerization products, as well as that of analogous steroidal olefins as side-products, was found to be dependant on the reaction conditions. The formylation reaction tolerates various functional groups on the A and B rings of the steroids.

Original languageEnglish
Pages (from-to)777-781
Number of pages5
JournalSteroids
Volume67
Issue number9
DOIs
Publication statusPublished - 2002

Fingerprint

Carbonylation
Palladium
Steroids
Alkenes
Isomerization
Functional groups
Hydrogen
Derivatives
16-androstene
tributyltin

Keywords

  • 17-Formyl-steroids
  • 17-Iodo-16-enes
  • Carbonylation
  • Palladium catalysts
  • Steroids
  • Tributyltin hydride

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Molecular Biology

Cite this

Facile synthesis of 17-formyl steroids via palladium-catalyzed homogeneous carbonylation reaction. / Petz, Andrea; Horváth, Judit; Tuba, Zoltán; Pintér, Zoltán; Kollár, L.

In: Steroids, Vol. 67, No. 9, 2002, p. 777-781.

Research output: Contribution to journalArticle

Petz, Andrea ; Horváth, Judit ; Tuba, Zoltán ; Pintér, Zoltán ; Kollár, L. / Facile synthesis of 17-formyl steroids via palladium-catalyzed homogeneous carbonylation reaction. In: Steroids. 2002 ; Vol. 67, No. 9. pp. 777-781.
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