Facile ring opening of 2,3-epoxy-steroids with aromatic amines in ionic liquids

Anita Horváth, R. Skoda-Földes, Sándor Mahó, Z. Berente, L. Kollár

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Efficient ring opening of steroidal 2,3-epoxides with stoichiometric amount of aromatic amines has been carried out using an ionic liquid ([bmim]+[BF4]-) both as solvent and catalyst. The reactions were completely regio- and stereoselective in each case. The aminoalcohol products have chair conformations in ring A. The ionic liquid-mediated ring opening can efficiently be carried out with aliphatic amines like morpholine as well.

Original languageEnglish
Pages (from-to)706-711
Number of pages6
JournalSteroids
Volume71
Issue number8
DOIs
Publication statusPublished - Aug 2006

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Ionic Liquids
Amines
Steroids
Epoxy Compounds
Conformations
Catalysts
morpholine

Keywords

  • 2,3-Epoxy derivatives
  • Aminoalcohols
  • Ionic liquids
  • Steroids

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Molecular Biology

Cite this

Facile ring opening of 2,3-epoxy-steroids with aromatic amines in ionic liquids. / Horváth, Anita; Skoda-Földes, R.; Mahó, Sándor; Berente, Z.; Kollár, L.

In: Steroids, Vol. 71, No. 8, 08.2006, p. 706-711.

Research output: Contribution to journalArticle

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AU - Kollár, L.

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