Facile, High-Yielding Synthesis of 4-Functionalised 1,2,3-Triazoles via Amino- and Aryloxycarbonylation

Péter Szuroczki, Levente Molnár, Ágnes Dörnyei, László Kollár

Research output: Contribution to journalArticle

Abstract

4-Iodo-1,2,3-triazoles were synthesised via azide-alkyne cycloaddition of alkynyl Grignard reagent and benzyl azide followed by iodination reaction. The aminocarbonylation and aryloxycarbonylation of 4-iodo-1,2,3-triazoles were carried out in the presence of various N- and O-nucleophiles, resulting in the corresponding triazole-based 4-carboxamides and 4-esters, respectively. Both high-yielding reactions were carried out under mild conditions (atmospheric CO pressure, 70 °C).

Original languageEnglish
Pages (from-to)448-451
Number of pages4
JournalChemistrySelect
Volume5
Issue number2
DOIs
Publication statusPublished - Jan 16 2020

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Keywords

  • Aminocarbonylation
  • carbon monoxide
  • carbonylation
  • palladium
  • triazole

ASJC Scopus subject areas

  • Chemistry(all)

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