Extrinsic afferent systems to the dentate gyrus

Csaba Leranth, Tibor Hajszan

Research output: Chapter in Book/Report/Conference proceedingChapter

76 Citations (Scopus)

Abstract

The dentate gyrus is the first stage of the intrahippocampal, excitatory, trisynaptic loop, and a primary target of the majority of entorhinal afferents that terminate in a laminar fashion on granule cell dendrites and carry sensory information of multiple modalities about the external world. The electric activity of the trisynaptic pathway is controlled mainly by different types of local, GABAergic interneurons, and subcortical and commissural afferents. In this chapter we will outline the origin and postsynaptic targets in the dentate gyrus of chemically identified subcortical inputs. These systems are afferents originating from the medial septum/diagonal band of Broca GABAergic and cholinergic neurons, neurochemically distinct types of neurons located in the supramammillary area, serotonergic fibers from the median raphe, noradrenergic afferents from the pontine nucleus, locus ceruleus, dopamine axons originating in the ventral tegmental area, and the commissural projection system. Because of the physiological implications, these afferents are discussed in the context of the glutamatergic innervation of the dentate gyrus. One common feature of the extrinsic dentate afferent systems is that they originate from a relatively small number of neurons. However, the majority of these afferents are able to exert a powerful control over the electrical activity of the hippocampus. This strong influence is due to the fact that the majority of the extrinsic afferents terminate on a relatively small, but specific, populations of neurons that are able to control large areas of the hippocampal formation.

Original languageEnglish
Title of host publicationThe Dentate Gyrus
Subtitle of host publicationA Comprehensive Guide to Structure, Function, and Clinical Implications
PublisherElsevier
Pages63-84,799
ISBN (Print)0444530150, 9780444530158
DOIs
Publication statusPublished - Jan 1 2007

Publication series

NameProgress in Brain Research
Volume163
ISSN (Print)0079-6123

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Keywords

  • acetylcholine
  • commissural connection
  • dopamine
  • median raphe
  • noradrenaline
  • septum
  • serotonin
  • supramammillary area

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Leranth, C., & Hajszan, T. (2007). Extrinsic afferent systems to the dentate gyrus. In The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications (pp. 63-84,799). (Progress in Brain Research; Vol. 163). Elsevier. https://doi.org/10.1016/S0079-6123(07)63004-0