Extreme resilience in cochleate nanoparticles

Tamás Bozó, Richárd Brecska, P. Gróf, M. Kellermayer

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cochleates, prospective nanoscale drug delivery vehicles, are rolls of negatively charged phospholipid membrane layers. The membrane layers are held together by calcium ions; however, neither the magnitude of membrane interaction forces nor the overall mechanical properties of cochleates have been known. Here, we manipulated individual nanoparticles with atomic force microscopy to characterize their nanomechanical behavior. Their stiffness (4.2-12.5 N/m) and membrane-rupture forces (45.3-278 nN) are orders of magnitude greater than those of the tough viral nanoshells. Even though the fundamental building material of cochleates is a fluid membrane, the combination of supramolecular geometry, the cross-linking action of calcium, and the tight packing of the ions apparently lead to extreme mechanical resilience. The supramolecular design of cochleates may provide efficient protection for encapsulated materials and give clues to understanding biomolecular structures of similar design, such as the myelinated axon.

Original languageEnglish
Pages (from-to)839-845
Number of pages7
JournalLangmuir
Volume31
Issue number2
DOIs
Publication statusPublished - Jan 20 2015

Fingerprint

resilience
Nanoparticles
membranes
Membranes
nanoparticles
calcium
Calcium
Nanoshells
Ions
axons
Atomic Force Microscopy
Phospholipids
Drug delivery
Axons
Rupture
Atomic force microscopy
stiffness
delivery
vehicles
ions

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy
  • Medicine(all)

Cite this

Extreme resilience in cochleate nanoparticles. / Bozó, Tamás; Brecska, Richárd; Gróf, P.; Kellermayer, M.

In: Langmuir, Vol. 31, No. 2, 20.01.2015, p. 839-845.

Research output: Contribution to journalArticle

Bozó, Tamás ; Brecska, Richárd ; Gróf, P. ; Kellermayer, M. / Extreme resilience in cochleate nanoparticles. In: Langmuir. 2015 ; Vol. 31, No. 2. pp. 839-845.
@article{63658c382bc64e75957e38ac03c6f48e,
title = "Extreme resilience in cochleate nanoparticles",
abstract = "Cochleates, prospective nanoscale drug delivery vehicles, are rolls of negatively charged phospholipid membrane layers. The membrane layers are held together by calcium ions; however, neither the magnitude of membrane interaction forces nor the overall mechanical properties of cochleates have been known. Here, we manipulated individual nanoparticles with atomic force microscopy to characterize their nanomechanical behavior. Their stiffness (4.2-12.5 N/m) and membrane-rupture forces (45.3-278 nN) are orders of magnitude greater than those of the tough viral nanoshells. Even though the fundamental building material of cochleates is a fluid membrane, the combination of supramolecular geometry, the cross-linking action of calcium, and the tight packing of the ions apparently lead to extreme mechanical resilience. The supramolecular design of cochleates may provide efficient protection for encapsulated materials and give clues to understanding biomolecular structures of similar design, such as the myelinated axon.",
author = "Tam{\'a}s Boz{\'o} and Rich{\'a}rd Brecska and P. Gr{\'o}f and M. Kellermayer",
year = "2015",
month = "1",
day = "20",
doi = "10.1021/la504428x",
language = "English",
volume = "31",
pages = "839--845",
journal = "Langmuir",
issn = "0743-7463",
publisher = "American Chemical Society",
number = "2",

}

TY - JOUR

T1 - Extreme resilience in cochleate nanoparticles

AU - Bozó, Tamás

AU - Brecska, Richárd

AU - Gróf, P.

AU - Kellermayer, M.

PY - 2015/1/20

Y1 - 2015/1/20

N2 - Cochleates, prospective nanoscale drug delivery vehicles, are rolls of negatively charged phospholipid membrane layers. The membrane layers are held together by calcium ions; however, neither the magnitude of membrane interaction forces nor the overall mechanical properties of cochleates have been known. Here, we manipulated individual nanoparticles with atomic force microscopy to characterize their nanomechanical behavior. Their stiffness (4.2-12.5 N/m) and membrane-rupture forces (45.3-278 nN) are orders of magnitude greater than those of the tough viral nanoshells. Even though the fundamental building material of cochleates is a fluid membrane, the combination of supramolecular geometry, the cross-linking action of calcium, and the tight packing of the ions apparently lead to extreme mechanical resilience. The supramolecular design of cochleates may provide efficient protection for encapsulated materials and give clues to understanding biomolecular structures of similar design, such as the myelinated axon.

AB - Cochleates, prospective nanoscale drug delivery vehicles, are rolls of negatively charged phospholipid membrane layers. The membrane layers are held together by calcium ions; however, neither the magnitude of membrane interaction forces nor the overall mechanical properties of cochleates have been known. Here, we manipulated individual nanoparticles with atomic force microscopy to characterize their nanomechanical behavior. Their stiffness (4.2-12.5 N/m) and membrane-rupture forces (45.3-278 nN) are orders of magnitude greater than those of the tough viral nanoshells. Even though the fundamental building material of cochleates is a fluid membrane, the combination of supramolecular geometry, the cross-linking action of calcium, and the tight packing of the ions apparently lead to extreme mechanical resilience. The supramolecular design of cochleates may provide efficient protection for encapsulated materials and give clues to understanding biomolecular structures of similar design, such as the myelinated axon.

UR - http://www.scopus.com/inward/record.url?scp=84922454546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922454546&partnerID=8YFLogxK

U2 - 10.1021/la504428x

DO - 10.1021/la504428x

M3 - Article

C2 - 25521248

AN - SCOPUS:84922454546

VL - 31

SP - 839

EP - 845

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 2

ER -