Extreme differences in SLCO1B3 functional polymorphisms in Roma and Hungarian populations

Agnes Nagy, Renata Szalai, Lili Magyari, Judit Bene, Kalman Toth, Bela Melegh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Variants in SLCO1B3 transporter are linked to disposition and uptake of drugs and show high degree of heterogeneity between populations. A total of 467 Roma and 448 Hungarian subjects were genotyped for SLCO1B3 c.334T>G and c.1683-5676A>G variant alleles by PCR-RFLP assay and direct sequencing. We found significant differences in the frequencies of homozygous variant genotypes of SLCO1B3 334GG (41.54% vs. 8.04%, p<. 0.001) and 1683-5676GG (0.43% vs 2.01%, p= 0.028) between Romas and Hungarians. A significantly increased prevalence was found in SLCO1B3 1683-5676G allele frequency in Hungarians compared to the Roma population (15.07% vs. 3.43%, p≤. 0.001). The frequency of SLCO1B3 334G allele was significantly increased in Roma population compared to Hungarians (70.56% vs 52.23%, p= 0.001). The LD values between the examined SNPs were 80 and 90 in Roma and in Hungarian samples, respectively. Our results highlight notable pharmacogenetic differences between Roma and Hungarian populations, which may have therapeutic implications.

Original languageEnglish
Pages (from-to)1246-1251
Number of pages6
JournalEnvironmental Toxicology and Pharmacology
Volume39
Issue number3
DOIs
Publication statusPublished - May 1 2015

Keywords

  • Hungarian
  • Polymorphism
  • Roma
  • SLCO1B3

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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