Extravascular lung water index as a sign of developing sepsis in burns

Z. Bognar, V. Foldi, B. Rezman, L. Bogár, C. Csontos

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Sepsis and multiple organ failure remain the leading cause of mortality and morbidity in burns. The aim of our study was to analyse the predictive value of extravascular lung water index (EVLWI) in the development of severe septic complications and mortality. The records of 28 patients with total burned surface area >20% were analysed (EVLWI, procalcitonin (PCT), intrathoracic blood volume index (ITBVI), positive end-expiratory pressure (PEEP), Baltimore Sepsis Scale (BaSS)). Diagnosis of infection (day 0) was based on consensus conference of the American Burn Association. EVLWI correlated with PCT (r = 0.597), and PEEP (r = 0.501) on day 0 and with BaSS (r = 0.524) and MODS (r = 0.513) from day 1. EVLWI was elevated (p <0.05) from one day before diagnosis of infection, PCT was higher (p <0.05) from day 0 only. ROC analysis for EVLWI on day -1 and for PCT on day 0 showed similar areas under curve (0.760; 0.766). EVLWI >9 ml kg-1 on day -1 predicted sepsis (89% sensitivity, 72% specificity). After antibiotic treatment EVLWI remained high in non-survivors, decreased in survivors, whereas PCT decreased in both groups. Our data suggest that EVLWI is an early warning sign of developing infection and its continuous elevation can predict poor prognosis in burns.

Original languageEnglish
Pages (from-to)1263-1270
Number of pages8
JournalBurns
Volume36
Issue number8
DOIs
Publication statusPublished - Dec 2010

Fingerprint

Extravascular Lung Water
Burns
Sepsis
Calcitonin
Baltimore
Multiple Organ Failure
Positive-Pressure Respiration
Mortality
Infection
Blood Volume
Survivors
Anti-Bacterial Agents
Morbidity
Sensitivity and Specificity

Keywords

  • Burn
  • Extravascular lung water index
  • Procalcitonin
  • Scoring systems
  • Sepsis

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine
  • Surgery

Cite this

Extravascular lung water index as a sign of developing sepsis in burns. / Bognar, Z.; Foldi, V.; Rezman, B.; Bogár, L.; Csontos, C.

In: Burns, Vol. 36, No. 8, 12.2010, p. 1263-1270.

Research output: Contribution to journalArticle

Bognar, Z, Foldi, V, Rezman, B, Bogár, L & Csontos, C 2010, 'Extravascular lung water index as a sign of developing sepsis in burns', Burns, vol. 36, no. 8, pp. 1263-1270. https://doi.org/10.1016/j.burns.2010.04.006
Bognar, Z. ; Foldi, V. ; Rezman, B. ; Bogár, L. ; Csontos, C. / Extravascular lung water index as a sign of developing sepsis in burns. In: Burns. 2010 ; Vol. 36, No. 8. pp. 1263-1270.
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