Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets

G. Szabó, Fatemeh Momen-Heravi

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Extracellular vesicles (EVs) are membranous vesicles originating from different cells in the liver. The pathophysiological role of EVs is increasingly recognized in liver diseases, including alcoholic liver disease, NAFLD, viral hepatitis and hepatocellular carcinoma. EVs, via their cargo, can provide communication between different cell types in the liver and between organs. EVs are explored as biomarkers of disease and could also represent therapeutic targets and vehicles for treatment delivery. Here, we review advances in understanding the role of EVs in liver diseases and discuss their utility in biomarker discovery and therapeutics.

Original languageEnglish
Pages (from-to)455-466
Number of pages12
JournalNature Reviews Gastroenterology and Hepatology
Volume14
Issue number8
DOIs
Publication statusPublished - Aug 1 2017

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Liver Diseases
Biomarkers
Therapeutics
Alcoholic Liver Diseases
Liver
Hepatitis
Hepatocellular Carcinoma
Extracellular Vesicles

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets. / Szabó, G.; Momen-Heravi, Fatemeh.

In: Nature Reviews Gastroenterology and Hepatology, Vol. 14, No. 8, 01.08.2017, p. 455-466.

Research output: Contribution to journalReview article

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