Extracellular signal-regulated kinases in pain of peripheral origin

John P M White, Mario Cibelli, Antonio Rei Fidalgo, I. Nagy

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Activation of members of the family of enzymes known as extracellular signal-regulated kinases (ERKs) is now known to be involved in the development and/or maintenance of the pain associated with many inflammatory conditions, such as herniated spinal disc pain, chronic inflammatory articular pain, and the pain associated with bladder inflammation. Moreover, ERKs are implicated in the development of neuropathic pain signs in animals which are subjected to the lumbar 5 spinal nerve ligation model and the chronic constriction injury model of neuropathic pain. The position has now been reached where all scientists working on pain subjects ought to be aware of the importance of ERKs, if only because certain of these enzymes are increasingly employed as experimental markers of nociceptive processing. Here, we introduce the reader, first, to the intracellular context in which these enzymes function. Thereafter, we consider the involvement of ERKs in mediating nociceptive signalling to the brain resulting from noxious stimuli at the periphery which will be interpreted by the brain as pain of peripheral origin.

Original languageEnglish
Pages (from-to)8-17
Number of pages10
JournalEuropean Journal of Pharmacology
Volume650
Issue number1
DOIs
Publication statusPublished - Jan 10 2011

Fingerprint

Extracellular Signal-Regulated MAP Kinases
Pain
Neuralgia
Enzymes
Intervertebral Disc Displacement
Spinal Nerves
Brain
Constriction
Chronic Pain
Ligation
Urinary Bladder
Joints
Maintenance
Inflammation
Wounds and Injuries

Keywords

  • ERK
  • Inflammation
  • Intracellular signalling
  • MAPK
  • Neuropathy
  • Pain

ASJC Scopus subject areas

  • Pharmacology

Cite this

Extracellular signal-regulated kinases in pain of peripheral origin. / White, John P M; Cibelli, Mario; Fidalgo, Antonio Rei; Nagy, I.

In: European Journal of Pharmacology, Vol. 650, No. 1, 10.01.2011, p. 8-17.

Research output: Contribution to journalArticle

White, John P M ; Cibelli, Mario ; Fidalgo, Antonio Rei ; Nagy, I. / Extracellular signal-regulated kinases in pain of peripheral origin. In: European Journal of Pharmacology. 2011 ; Vol. 650, No. 1. pp. 8-17.
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