Extracellular matrix motion and early morphogenesis

Rajprasad Loganathan, Brenda J. Rongish, Christopher M. Smith, Michael B. Filla, Andras Czirok, Bertrand Bénazéraf, Charles D. Little

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

For over a century, embryologists who studied cellular motion in early amniotes generally assumed that morphogenetic movement reflected migration relative to a static extracellular matrix (ECM) scaffold. However, as we discuss in this Review, recent investigations reveal that the ECM is also moving during morphogenesis. Time-lapse studies show how convective tissue displacement patterns, as visualized by ECM markers, contribute to morphogenesis and organogenesis. Computational image analysis distinguishes between cell-autonomous (active) displacements and convection caused by large-scale (composite) tissue movements. Modern quantification of large-scale ‘total’ cellular motion and the accompanying ECM motion in the embryo demonstrates that a dynamic ECM is required for generation of the emergent motion patterns that drive amniote morphogenesis.

Original languageEnglish
Pages (from-to)2056-2065
Number of pages10
JournalDevelopment (Cambridge)
Volume143
Issue number12
DOIs
Publication statusPublished - Jun 15 2016

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Keywords

  • Amniote morphogenesis
  • Emergent patterns
  • Extracellular matrix dynamics
  • Tissue-scale motion

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

Cite this

Loganathan, R., Rongish, B. J., Smith, C. M., Filla, M. B., Czirok, A., Bénazéraf, B., & Little, C. D. (2016). Extracellular matrix motion and early morphogenesis. Development (Cambridge), 143(12), 2056-2065. https://doi.org/10.1242/dev.127886