Extracellular matrix molecules and their possible roles in the regeneration of frog nervous system

C. Matesz, Laszlo Modis, Gabor Halasi, Zsuzsa M. Szigeti, S. Felszeghy, Timea Bacskai, György Szekely

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Recent biochemical and histochemical analyses explored different components of the extracellular matrix (ECM) in the nervous system, and either permissive or non-permissive roles in neuronal development and regeneration were suggested. The aim of this study was to detect the distribution pattern of a few of these molecules in the nervous system of intact frogs and during nerve regeneration. The hyaluronan (HA) and tenascin C reactions were negative in the peripheral nerves, but appeared in their entry zones. In the CNS, different populations of neurons were surrounded with HA and tenascin C-positive material, forming a perineuronal net (PN). The phosphacan reaction was weakly positive in the PNS, and a moderate intensity was detected in the entry zone and in the PN. Laminin and fibronectin immunoreactivity was strong in the PNS, but laminin could not be detected in the CNS. In animals with cut and regenerating vestibulocochlear nerve, the distribution of the ECM molecules in the CNS and PNS characteristically changed from that of the normal pattern. Our results showed a non-homogenous distribution of ECM components in the frog nervous system that could be associated with their different roles in physiological and pathological processes.

Original languageEnglish
Pages (from-to)526-531
Number of pages6
JournalBrain Research Bulletin
Volume66
Issue number4-6
DOIs
Publication statusPublished - Sep 15 2005

Fingerprint

Anura
Nervous System
Extracellular Matrix
Tenascin
Regeneration
Laminin
Hyaluronic Acid
Class 5 Receptor-Like Protein Tyrosine Phosphatases
Vestibulocochlear Nerve
Physiological Phenomena
Nerve Regeneration
Pathologic Processes
Peripheral Nerves
Fibronectins
Neurons
Population

Keywords

  • Fibronectin
  • Hyaluronan
  • Laminin
  • Phosphacan
  • Tenascin C

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Extracellular matrix molecules and their possible roles in the regeneration of frog nervous system. / Matesz, C.; Modis, Laszlo; Halasi, Gabor; Szigeti, Zsuzsa M.; Felszeghy, S.; Bacskai, Timea; Szekely, György.

In: Brain Research Bulletin, Vol. 66, No. 4-6, 15.09.2005, p. 526-531.

Research output: Contribution to journalArticle

Matesz, C. ; Modis, Laszlo ; Halasi, Gabor ; Szigeti, Zsuzsa M. ; Felszeghy, S. ; Bacskai, Timea ; Szekely, György. / Extracellular matrix molecules and their possible roles in the regeneration of frog nervous system. In: Brain Research Bulletin. 2005 ; Vol. 66, No. 4-6. pp. 526-531.
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