Extracellular enzymes and mycotoxins as virulence factors in Fusarium and Aspergillus keratitis

Kanesan Panneer Selvam, Y. Randhir Babu Singh, Coimbatore Subramanian Shobana, Nair Kalesh Karunakaran, Csaba Vágvölgyi, László Kredics, Raid Saleem Al-Baradie, Palanisamy Manikandan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The incidence of Fusarium and Aspergillus keratitis is on alarming rise with its burden increasing by the fact that they can produce an array of extra cellular enzymes and mycotoxins which act as virulence factors. In this context, 154 isolates of Fusarium spp. and Aspergillus spp. were screened for extracellular enzymes production. Further, representative isolates from the two genera were analyzed for mycotoxin production. Both genera were able to produce an array of extracellular enzymes. It was noted that protease and lipase are actively involved in Fusarium and Aspergillus keratitis. Aflatoxins were detected from Aspergillus spp., however no mycotoxins were detected from Fusarium spp. The study concludes that the extra cellular protease and lipase are cause of concern since it play important roles in pathogenesis of Fusarium and Aspergillus keratitis.

Original languageEnglish
Pages (from-to)479-490
Number of pages12
JournalBiosciences Biotechnology Research Asia
Volume11
Issue number2
DOIs
Publication statusPublished - Aug 1 2014

Keywords

  • Aspergillus
  • Extracellular enzymes
  • Fusarium
  • Keratitis
  • Mycotoxins

ASJC Scopus subject areas

  • Biotechnology
  • Agronomy and Crop Science
  • Drug Discovery

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    Selvam, K. P., Singh, Y. R. B., Shobana, C. S., Karunakaran, N. K., Vágvölgyi, C., Kredics, L., Al-Baradie, R. S., & Manikandan, P. (2014). Extracellular enzymes and mycotoxins as virulence factors in Fusarium and Aspergillus keratitis. Biosciences Biotechnology Research Asia, 11(2), 479-490. https://doi.org/10.13005/bbra/1298