Extension of the CD4+Foxp3+CD25-/low regulatory T-cell subpopulation in type 1 diabetes mellitus

András Zóka, Gábor Barna, Anikó Somogyi, Györgyi Mzes, Ágnes Oláh, Zahra Al-Aissa, Orsolya Hadarits, Katalin Kiss, Gábor Firneisz

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Regulatory T-cells (Treg) have a crucial role in limiting physiologic autoreactivity. Foxp3 is a master regulator transcription factor of Treg differentiation and active Treg cells express high levels of IL-2 receptor α-chain (CD25). The aim of our study was to assess the key markers of Treg cell function in type 1 diabetic (T1DM) and control subjects by flow cytometry. The proportion of CD25-/low cells among CD4+Foxp3+ Treg cells was higher in T1DM patients that might suggest a shifted proportion of the incomplete/reserve and the fully active (CD4+Foxp3+CD25+) Treg cell subpopulations in T1DM, similarly to other Th1-mediated autoimmune diseases. In addition to the decreased expression of CD25 and CTLA-4 in T1DM patients, a positive correlation was observed between the CD25 expression on CD4+ and the CTLA-4 expression in CD8- T-lymphocytes both in the T1DM and in the healthy control group. Our results suggest an impaired balance of CD25+ and CD25-/low Treg cells in T1DM which might reflect a decreased late phase peripheral Treg activation even in patients with a mean disease duration of more than a decade.

Original languageEnglish
Pages (from-to)289-297
Number of pages9
JournalAutoimmunity
Volume48
Issue number5
DOIs
Publication statusPublished - Aug 1 2015

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Keywords

  • Autoreactivity
  • CD25
  • Foxp3
  • Immune regulation
  • Insulitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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