Extension of the applicability of ΔJ-values for the configurational assignment of diastereomeric phosphate-modified dideoxynucleotides

Daisy Machytka, E. Gács-Baitz, Zsuzsa Tegyey

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The stereochemical assignment of dinucleoside-S-p-nitrobenzyl- phosphorothioates by MR spectroscopy is reported. It was found that the method based on the difference of the vicinal phosphorus-carbon coupling constants (ΔJ =3 J(C4',P) - 3J(C2',P)) can widely be applied for the determination of the configuration at the phosphorus atom in phosphate- modified dideoxynucleotides.

Original languageEnglish
Pages (from-to)2311-2322
Number of pages12
JournalNucleosides and Nucleotides
Volume17
Issue number12
Publication statusPublished - 1998

Fingerprint

Dideoxynucleotides
Phosphorus
Phosphates
Magnetic Resonance Spectroscopy
Carbon
Spectroscopy
Atoms

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Cite this

Extension of the applicability of ΔJ-values for the configurational assignment of diastereomeric phosphate-modified dideoxynucleotides. / Machytka, Daisy; Gács-Baitz, E.; Tegyey, Zsuzsa.

In: Nucleosides and Nucleotides, Vol. 17, No. 12, 1998, p. 2311-2322.

Research output: Contribution to journalArticle

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