Extended tumor growth model for combined therapy

Daniel Andras Drexler, Tamas Ferenci, Levente Kovacs

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Mathematical modeling of tumor growth dynamics may have great impact on modern medicine. The dynamical model of tumor growth which describes the effect of drugs can be used e.g., for therapy optimization, therapy supervision, drug development. Based on a single drug tumor growth model, we create a model that can be used to describe the effect of two drugs. The extended model is created using formal reaction kinetics analogy, thus the meaning of the equations is interpretable for experts not familiar with differential equations. We carry out parametric identification using nonlinear mixed-effect model, for the identification we use measurements from mice experiments carried out using bevacizumab and fluorouracil treatment. The results of the identification show that the measurements can be reproduced using the model with small error, and the interpatient variability for most of the parameters is relatively low.

Original languageEnglish
Title of host publication2019 IEEE International Conference on Systems, Man and Cybernetics, SMC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages886-891
Number of pages6
ISBN (Electronic)9781728145693
DOIs
Publication statusPublished - Oct 2019
Event2019 IEEE International Conference on Systems, Man and Cybernetics, SMC 2019 - Bari, Italy
Duration: Oct 6 2019Oct 9 2019

Publication series

NameConference Proceedings - IEEE International Conference on Systems, Man and Cybernetics
Volume2019-October
ISSN (Print)1062-922X

Conference

Conference2019 IEEE International Conference on Systems, Man and Cybernetics, SMC 2019
CountryItaly
CityBari
Period10/6/1910/9/19

Fingerprint

Tumors
Identification (control systems)
Drug therapy
Reaction kinetics
Medicine
Differential equations
Experiments

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Control and Systems Engineering
  • Human-Computer Interaction

Cite this

Drexler, D. A., Ferenci, T., & Kovacs, L. (2019). Extended tumor growth model for combined therapy. In 2019 IEEE International Conference on Systems, Man and Cybernetics, SMC 2019 (pp. 886-891). [8914569] (Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics; Vol. 2019-October). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/SMC.2019.8914569

Extended tumor growth model for combined therapy. / Drexler, Daniel Andras; Ferenci, Tamas; Kovacs, Levente.

2019 IEEE International Conference on Systems, Man and Cybernetics, SMC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 886-891 8914569 (Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics; Vol. 2019-October).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Drexler, DA, Ferenci, T & Kovacs, L 2019, Extended tumor growth model for combined therapy. in 2019 IEEE International Conference on Systems, Man and Cybernetics, SMC 2019., 8914569, Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics, vol. 2019-October, Institute of Electrical and Electronics Engineers Inc., pp. 886-891, 2019 IEEE International Conference on Systems, Man and Cybernetics, SMC 2019, Bari, Italy, 10/6/19. https://doi.org/10.1109/SMC.2019.8914569
Drexler DA, Ferenci T, Kovacs L. Extended tumor growth model for combined therapy. In 2019 IEEE International Conference on Systems, Man and Cybernetics, SMC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 886-891. 8914569. (Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics). https://doi.org/10.1109/SMC.2019.8914569
Drexler, Daniel Andras ; Ferenci, Tamas ; Kovacs, Levente. / Extended tumor growth model for combined therapy. 2019 IEEE International Conference on Systems, Man and Cybernetics, SMC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 886-891 (Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics).
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