Extended Interneuronal Network of the Dentate Gyrus

Gergely G. Szabo, Xi Du, Mikko Oijala, C. Varga, Jack M. Parent, Ivan Soltesz

Research output: Contribution to journalArticle

16 Citations (Scopus)


Local interneurons control principal cells within individual brain areas, but anecdotal observations indicate that interneuronal axons sometimes extend beyond strict anatomical boundaries. Here, we use the case of the dentate gyrus (DG) to show that boundary-crossing interneurons with cell bodies in CA3 and CA1 constitute a numerically significant and diverse population that relays patterns of activity generated within the CA regions back to granule cells. These results reveal the existence of a sophisticated retrograde GABAergic circuit that fundamentally extends the canonical interneuronal network.

Original languageEnglish
Pages (from-to)1262-1268
Number of pages7
JournalCell Reports
Issue number6
Publication statusPublished - Aug 8 2017


  • GABA
  • hippocampus
  • inhibition
  • network

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Szabo, G. G., Du, X., Oijala, M., Varga, C., Parent, J. M., & Soltesz, I. (2017). Extended Interneuronal Network of the Dentate Gyrus. Cell Reports, 20(6), 1262-1268. https://doi.org/10.1016/j.celrep.2017.07.042