Expression Profiles of Peripheral CD160 + Lymphocytes During the Course of Healthy Human Pregnancy

A. Barakonyi, Renata Weisdorn, Eva Miko, Peter Varga, Jozsef Bodis, J. Szekeres-Barthó, L. Szereday

Research output: Contribution to journalArticle

Abstract

Problem CD160 receptor is expressed by natural killer (NK) and T-cell subsets, and after activation, it could enhance cytotoxicity or pro-inflammatory cytokine production on NK cells. Here, we investigated the phenotype of peripheral CD160 + cells during healthy pregnancy. Method of study We analyzed the expression of CD69 activation marker, gamma/delta TCR, and NKG2A or NKG2D NK cell receptors on CD160 + lymphocytes of non-pregnant and healthy pregnant women at four different stages of pregnancy by flow cytometry. Results In our hands, CD160 receptor-positive lymphocytes were present during pregnancy; however, they had different characteristics depending on gestational age. During implantation, CD160 + cells showed low activation rate, decreased NK receptor expression while 40% of Vδ2 + T cells expressed CD160 receptor. In turn, all the above parameters increased as pregnancy proceeds. Conclusion Our results indicate that CD160 + lymphocytes could be able to play a role in the maintenance of healthy pregnancy.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalAmerican Journal of Reproductive Immunology
Volume66
Issue number2
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Lymphocytes
Pregnancy
Pregnancy Maintenance
Natural Killer Cell Receptors
Natural Killer T-Cells
T-Lymphocyte Subsets
Natural Killer Cells
Gestational Age
Pregnant Women
Flow Cytometry
Cytokines
T-Lymphocytes
Phenotype

Keywords

  • γ/δ T cells
  • CD160 receptor
  • Healthy pregnancy
  • NK receptors

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Expression Profiles of Peripheral CD160 + Lymphocytes During the Course of Healthy Human Pregnancy. / Barakonyi, A.; Weisdorn, Renata; Miko, Eva; Varga, Peter; Bodis, Jozsef; Szekeres-Barthó, J.; Szereday, L.

In: American Journal of Reproductive Immunology, Vol. 66, No. 2, 08.2011, p. 137-142.

Research output: Contribution to journalArticle

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