Expression of vascular endothelial growth factor in diffuse malignant pleural mesothelioma

Jens Ekkehard König, E. Tolnay, Thorsten Wiethege, Klaus Michael Müller

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Angiogenesis is an important part of normal and pathological processes, including tumour growth, metastasis, inflammation and wound healing. VEGF is the best known angiogenic factor, implicated in tumour-associated microvascular hyperpermeability and carcinogenesis. We investigated 103 malignant pleural mesotheliomas, analysing the expression of vascular endothelial growth factor using immunohistochemistry and insitu hybridization. The grade of microvessel density was assessed with the aid of anti-factor-VIII antibodies. An increased expression of VEGF was found in biphasic and epithelioid mesotheliomas, correlating in a statistically significant manner (P <0.042). Insitu hybridization confirmed the specificity of VEGF mRNA expression. There was a robust correlation between VEGF expression and increased microvessel density (P <O.OO1), and positive mesotheliomas had significantly higher microvessel densities than negative specimens. There was also a significant correlation between microvessel density and histological pattern. As growth pattern tended towards biphasic and sarcomatoid mesotheliomas the density of micovessels decreased (P <0.05).

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalVirchows Archiv
Volume435
Issue number1
DOIs
Publication statusPublished - 1999

Fingerprint

Vascular Endothelial Growth Factor A
Microvessels
Mesothelioma
Angiogenesis Inducing Agents
Factor VIII
Pathologic Processes
Growth
Wound Healing
Neoplasms
Carcinogenesis
Immunohistochemistry
Malignant Mesothelioma
Neoplasm Metastasis
Inflammation
Messenger RNA
Antibodies

Keywords

  • Diffuse malignant pleural mesothelioma
  • Factor VIII
  • Histological differentiation
  • Microvessel count
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Expression of vascular endothelial growth factor in diffuse malignant pleural mesothelioma. / König, Jens Ekkehard; Tolnay, E.; Wiethege, Thorsten; Müller, Klaus Michael.

In: Virchows Archiv, Vol. 435, No. 1, 1999, p. 8-12.

Research output: Contribution to journalArticle

König, Jens Ekkehard ; Tolnay, E. ; Wiethege, Thorsten ; Müller, Klaus Michael. / Expression of vascular endothelial growth factor in diffuse malignant pleural mesothelioma. In: Virchows Archiv. 1999 ; Vol. 435, No. 1. pp. 8-12.
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