Expression of vascular endothelial growth factor in diffuse malignant pleural mesothelioma

Jens Ekkehard König, Edina Tolnay, Thorsten Wiethege, Klaus Michael Müller

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54 Citations (Scopus)


Angiogenesis is an important part of normal and pathological processes, including tumour growth, metastasis, inflammation and wound healing. VEGF is the best known angiogenic factor, implicated in tumour-associated microvascular hyperpermeability and carcinogenesis. We investigated 103 malignant pleural mesotheliomas, analysing the expression of vascular endothelial growth factor using immunohistochemistry and insitu hybridization. The grade of microvessel density was assessed with the aid of anti-factor-VIII antibodies. An increased expression of VEGF was found in biphasic and epithelioid mesotheliomas, correlating in a statistically significant manner (P < 0.042). Insitu hybridization confirmed the specificity of VEGF mRNA expression. There was a robust correlation between VEGF expression and increased microvessel density (P < O.OO1), and positive mesotheliomas had significantly higher microvessel densities than negative specimens. There was also a significant correlation between microvessel density and histological pattern. As growth pattern tended towards biphasic and sarcomatoid mesotheliomas the density of micovessels decreased (P < 0.05).

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalVirchows Archiv
Issue number1
Publication statusPublished - Aug 3 1999


  • Diffuse malignant pleural mesothelioma
  • Factor VIII
  • Histological differentiation
  • Microvessel count
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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