Expression of thrombospondin-1 (TSP1) and its receptor (CD36) in healthy and diseased human skin

A. Begany, M. Simon, N. Dehmel, J. Hunyadi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In the present study, an analysis was made of the expression pattern of thrombospondin-1 (TSP1) and its receptor (CD36) in skin biopsies obtained from healthy volunteers and from patients with lichen planus, lupus erythematosus, cutaneous T-cell lymphoma and psoriasis vulgaris. Using monoclonal antibodies against TSP1 in biopsies from the healthy volunteers and from both clinically involved and uninvolved skin of the patients, a specific peroxidase-positive reaction was detected around the sweat glands in the dermis. In all cases investigated, the CD36-positive lesional keratinocytes remained TSP1-negative. These findings favour the hypothesis that CD36-positive keratinocytes might have some functional relevance via oxidized low-density lipoprotein and/or collagen fibrils, without any connection with TSP1.

Original languageEnglish
Pages (from-to)269-272
Number of pages4
JournalActa Dermato-Venereologica
Volume74
Issue number4
Publication statusPublished - Jan 1 1994

Keywords

  • adhesion molecules
  • human keratinocytes
  • immunohistochemistry
  • skin immune system
  • sweat glands

ASJC Scopus subject areas

  • Dermatology

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