In the present study an analysis was made of the expression pattern of thrombospondin-1 (TSP1) and its receptor (CD36) in skin biopsies obtained from healthy volunteers and from patients with lichen planus, cutaneous T-cell lymphoma, lupus erythematosus, and psoriasis vulgaris. Using monoclonal antibodies against TSP1 in biopsies from the healthy volunteers and from both clinically involved and uninvolved skin of the patients, a specific peroxidase-positive reaction was detected around the sweat glands and hair follicles in the dermis. In all cases investigated, the CD36-positive lesional keratinocytes remained TSP1-negative. These findings favour the hypothesis that CD36-positive lesional keratinocytes might have some functional relevance via collagen fibrils and/or oxidized low-density lipoprotein, without any connection with TSP1.
|Number of pages||3|
|Publication status||Published - Jan 1 1995|
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