THROMBOSPONDIN 1- UND THROMBOSPONDIN-REZEPTOR(CD36)-EXPRESSION IN GESUNDER UND ERKRANKTER MENSCHLICHER HAUT

Translated title of the contribution: Expression of thrombospondin-1 and the thrombospondin-receptor (CD36) in healthy and diseased human skin

M. Simon, A. Begany, N. Dehmel, J. Hunyadi

Research output: Contribution to journalArticle

Abstract

In the present study an analysis was made of the expression pattern of thrombospondin-1 (TSP1) and its receptor (CD36) in skin biopsies obtained from healthy volunteers and from patients with lichen planus, cutaneous T-cell lymphoma, lupus erythematosus, and psoriasis vulgaris. Using monoclonal antibodies against TSP1 in biopsies from the healthy volunteers and from both clinically involved and uninvolved skin of the patients, a specific peroxidase-positive reaction was detected around the sweat glands and hair follicles in the dermis. In all cases investigated, the CD36-positive lesional keratinocytes remained TSP1-negative. These findings favour the hypothesis that CD36-positive lesional keratinocytes might have some functional relevance via collagen fibrils and/or oxidized low-density lipoprotein, without any connection with TSP1.

Original languageGerman
Pages (from-to)164-166
Number of pages3
JournalAktuelle Dermatologie
Volume21
Issue number6
Publication statusPublished - Jan 1 1995

    Fingerprint

ASJC Scopus subject areas

  • Dermatology

Cite this