Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol

Subhendu Mukherjee, I. Lekli, Narasimman Gurusamy, Alberto A A Bertelli, Dipak K. Das

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Resveratrol increases longevity through SirT1, which is activated with NAD+ supplied by an anti-aging enzyme PBEF. SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds. The hearts expressed SirT, FoxO, and PBEF in the order of white wine > resveratrol > tyrosol > hydroxytyrosol > red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol > red wine > hydroxytyrosol > white wine > tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalFree Radical Biology and Medicine
Volume46
Issue number5
DOIs
Publication statusPublished - Mar 1 2009

Fingerprint

Wine
Proteins
Aging of materials
Insurance Benefits
4-hydroxyphenylethanol
resveratrol
3,4-dihydroxyphenylethanol
Cardiac Myocytes
NAD
Rats
Transcription Factors
Health
Apoptosis
Enzymes

Keywords

  • Cardioprotection
  • FoxO1
  • Hydroxytyrosol
  • Longevity
  • PBEF
  • Red wine
  • Resveratrol
  • SirT1
  • Tyrosol
  • White wine

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

Cite this

Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol. / Mukherjee, Subhendu; Lekli, I.; Gurusamy, Narasimman; Bertelli, Alberto A A; Das, Dipak K.

In: Free Radical Biology and Medicine, Vol. 46, No. 5, 01.03.2009, p. 573-578.

Research output: Contribution to journalArticle

Mukherjee, Subhendu ; Lekli, I. ; Gurusamy, Narasimman ; Bertelli, Alberto A A ; Das, Dipak K. / Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol. In: Free Radical Biology and Medicine. 2009 ; Vol. 46, No. 5. pp. 573-578.
@article{76a43285ecf14d1ab14908bc40997753,
title = "Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol",
abstract = "Resveratrol increases longevity through SirT1, which is activated with NAD+ supplied by an anti-aging enzyme PBEF. SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds. The hearts expressed SirT, FoxO, and PBEF in the order of white wine > resveratrol > tyrosol > hydroxytyrosol > red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol > red wine > hydroxytyrosol > white wine > tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival.",
keywords = "Cardioprotection, FoxO1, Hydroxytyrosol, Longevity, PBEF, Red wine, Resveratrol, SirT1, Tyrosol, White wine",
author = "Subhendu Mukherjee and I. Lekli and Narasimman Gurusamy and Bertelli, {Alberto A A} and Das, {Dipak K.}",
year = "2009",
month = "3",
day = "1",
doi = "10.1016/j.freeradbiomed.2008.11.005",
language = "English",
volume = "46",
pages = "573--578",
journal = "Free Radical Biology and Medicine",
issn = "0891-5849",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol

AU - Mukherjee, Subhendu

AU - Lekli, I.

AU - Gurusamy, Narasimman

AU - Bertelli, Alberto A A

AU - Das, Dipak K.

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Resveratrol increases longevity through SirT1, which is activated with NAD+ supplied by an anti-aging enzyme PBEF. SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds. The hearts expressed SirT, FoxO, and PBEF in the order of white wine > resveratrol > tyrosol > hydroxytyrosol > red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol > red wine > hydroxytyrosol > white wine > tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival.

AB - Resveratrol increases longevity through SirT1, which is activated with NAD+ supplied by an anti-aging enzyme PBEF. SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds. The hearts expressed SirT, FoxO, and PBEF in the order of white wine > resveratrol > tyrosol > hydroxytyrosol > red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol > red wine > hydroxytyrosol > white wine > tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival.

KW - Cardioprotection

KW - FoxO1

KW - Hydroxytyrosol

KW - Longevity

KW - PBEF

KW - Red wine

KW - Resveratrol

KW - SirT1

KW - Tyrosol

KW - White wine

UR - http://www.scopus.com/inward/record.url?scp=59249084680&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59249084680&partnerID=8YFLogxK

U2 - 10.1016/j.freeradbiomed.2008.11.005

DO - 10.1016/j.freeradbiomed.2008.11.005

M3 - Article

C2 - 19071213

AN - SCOPUS:59249084680

VL - 46

SP - 573

EP - 578

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

IS - 5

ER -