Expression of the follicular lymphoma variant translocation 1 gene in diffuse large B-cell lymphoma correlates with subtype and clinical outcome

David R. Czuchlewski, B. Csernus, Darya Bubman, Elizabeth Hyjek, Peter Martin, Amy Chadburn, Daniel M. Knowles, Ethel Cesarman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Sphingolipids serve an important role as effector molecules in signaling pathways bearing on apoptosis and cell survival. The balance between proapoptotic ceramide and prosurvival sphingosine-1-phosphate, sometimes termed the "sphingolipid rheostat," has received particular attention. Less well studied is the role of the follicular lymphoma variant translocation 1 (FVT1) gene, which was identified through its involvement in an atypical follicular lymphoma translocation and which encodes an enzyme in the synthetic pathway of ceramide. We investigated the expression of FVT1 in a variety of B-cell non-Hodgkin lymphomas and found that FVT1 is significantly underexpressed by germinal center-type diffuse large B-cell lymphoma (DLBCL) when compared with non-germinal center-type DLBCL, follicular lymphoma, and normal tonsil control samples. Increased expression of FVT1 correlated with decreased survival, suggesting that changes in the expression of FVT1 and in the concentrations of bioactive sphingolipids may be important in the pathogenesis and treatment of some types of DLBCL.

Original languageEnglish
Pages (from-to)957-962
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume130
Issue number6
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Follicular Lymphoma
Lymphoma, Large B-Cell, Diffuse
Sphingolipids
Genes
Ceramides
Germinal Center
Palatine Tonsil
B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Cell Survival
Apoptosis
Enzymes

Keywords

  • Ceramide
  • Follicular lymphoma variant translocation 1 gene
  • FVT1
  • Lymphoma
  • Sphingolipids

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Expression of the follicular lymphoma variant translocation 1 gene in diffuse large B-cell lymphoma correlates with subtype and clinical outcome. / Czuchlewski, David R.; Csernus, B.; Bubman, Darya; Hyjek, Elizabeth; Martin, Peter; Chadburn, Amy; Knowles, Daniel M.; Cesarman, Ethel.

In: American Journal of Clinical Pathology, Vol. 130, No. 6, 12.2008, p. 957-962.

Research output: Contribution to journalArticle

Czuchlewski, David R. ; Csernus, B. ; Bubman, Darya ; Hyjek, Elizabeth ; Martin, Peter ; Chadburn, Amy ; Knowles, Daniel M. ; Cesarman, Ethel. / Expression of the follicular lymphoma variant translocation 1 gene in diffuse large B-cell lymphoma correlates with subtype and clinical outcome. In: American Journal of Clinical Pathology. 2008 ; Vol. 130, No. 6. pp. 957-962.
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