Expression of syndecan-1 in human B cell chronic lymphocytic leukaemia

A. Sebestyén, I. Kovalszky, R. Mihalik, M. Gallai, J. Bocsi, E. Laszlö, S. Benedek, L. Sréter, L. Kopper

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Syndecan-1 is considered an important transmembrane proteoglycan in cell-microenvironment interactions, but its exact function in normal or in transformed B cells is still unknown. In this study, RNA was isolated from peripheral cells of chronic lymphocytic leukaemia (B-CLL) and 'normal', non- leukaemic patients, as controls. Reverse PCR showed no or very low syndecan- 1 mRNA expression in controls, while in 11/13 B-CLL the circulating leukaemic cells expressed syndecan-1. Similar results were obtained for interleukin- 1β (IL-1β) and interleukin-6 (IL-6). Furthermore, syndecan-1 protein was detected in the majority of circulating B-CLL cells by flow cytometry and immunocytochemistry using anti-syndecan-1 MAb. Control cells were practically negative. Further study is required to understand the biological significance of syndecan-1 on B-CLL cells.

Original languageEnglish
Pages (from-to)2273-2277
Number of pages5
JournalEuropean Journal of Cancer
Volume33
Issue number13
DOIs
Publication statusPublished - Nov 1 1997

Keywords

  • B-CLL
  • IL-1β
  • IL-6
  • Proteoglycan
  • Syndecan-1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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