Expression of SERCA2a is not regulated by calcineurin or upon mechanical unloading in skeletal muscle regeneration

Erno Zádor, Rita Fenyvesi, Frank Wuytack

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This study investigates to what extent the expression of the slow myosin heavy chain (MyHCI) isoform and the slow type sarcoplasmic reticulum Ca 2+ ATPase (SERCA2a) isoform are co-regulated in fibers of regenerating skeletal soleus muscle. Both overexpression of cain, a calcineurin inhibitor, or partial tenotomy prevented the expression of MyHCI but left SERCA2a expression unaffected in fibers of regenerating soleus muscles. These data complement those from different experimental models and clearly show that the expression of MyHCI and SERCA2a - the major proteins mediating, respectively, the slow type of contraction and relaxation - are not coregulated in regenerating soleus muscle.

Original languageEnglish
Pages (from-to)749-752
Number of pages4
JournalFEBS letters
Volume579
Issue number3
DOIs
Publication statusPublished - Jan 31 2005

    Fingerprint

Keywords

  • Calcineurin
  • MyHCI
  • Regeneration
  • SERCA2a
  • Tenotomy

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this